Clustering and analysis of protein families

Various sequence-motif and sequence-cluster databases have been integrated into a new resource known as InterPro. Because the contributing databases have different clustering principles and scoring sensitivities, the combined assignments complement each other for grouping protein families and deline...

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Bibliographic Details
Published in:Current Opinion in Structural Biology 2001-06, Vol.11 (3), p.334-339
Main Authors: Kriventseva, Evgenia V, Biswas, Margaret, Apweiler, Rolf
Format: Article
Language:English
Subjects:
Amino Acid Motifs
Databases, Factual
phylogenetic profiles
Phylogeny
protein clusters
Protein families
Proteins
Rosetta stone proteins
sequence alignment
Sequence Alignment - methods
sequence motifs
structure/functional relationships
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Summary:Various sequence-motif and sequence-cluster databases have been integrated into a new resource known as InterPro. Because the contributing databases have different clustering principles and scoring sensitivities, the combined assignments complement each other for grouping protein families and delineating domains. InterPro and new developments in the analysis of both the phylogenetic profiles of protein families and domain fusion events improve the prediction of specific functions for numerous proteins.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(00)00211-6