The Effect of Locally Delivered Controlled‐Release Doxycycline or Scaling and Root Planing on Periodontal Maintenance Patients Over 9 Months

• Published in: Journal of periodontology (1970) 2000-01, Vol.71 (1), p.22-30
• Main Authors: Garrett, Steven, Adams, Donald F., Bogle, Gary, Donly, Kevin, Hastings Drisko, Connie, Hallmon, William W., Brady Hancock, E., Hanes, Philip, Hawley, Charles E., Johnson, Lonnie, Kiger, Robert, Killoy, William, Mellonig, James T., Raab, Frank J., Ryder, Mark, Stoller, Norman, Polson, Alan, Wang, Hom‐Lay, Wolinsky, Lawrence E., Yukna, Raymond A., Harrold, Charles Q., Hill, Margaret, Johnson, Valerie Blanco, Lee Southard, G.
• Format: Article
• Language: English
• Subjects: Administration, Topical; Adult; Aged; Analysis of Variance; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; comparison studies; Delayed-Action Preparations; Dental Scaling; Dentistry; Doxycycline - administration & dosage; Doxycycline - analogs & derivatives; Doxycycline - therapeutic use; Female; Follow-Up Studies; Humans; Male; Middle Aged; Periodontal Attachment Loss - prevention & control; Periodontal Diseases - prevention & control; periodontal diseases/drug therapy; Periodontal diseases/therapy; Periodontal Pocket - prevention & control; planing; Recurrence; Root Planing; scaling; Single-Blind Method; Treatment Outcome
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2000.71.1.22

Background: This research report evaluates clinical changes resulting from local delivery of doxycycline hyclate (DH) or traditional scaling and root planing (SRP) in a group of patients undergoing supportive periodontal therapy (SPT). Methods: In all, 141 patients received either DH (67) or SRP (74) treatment in sites ≥5 mm on one‐half of their dentition at baseline and month 4. Results: Clinical results were determined at month 9. Baseline mean probing depth recordings were similar between the two groups (DH = 5.9 mm; SRP = 5.9 mm). Mean month 9 results showed similar clinical results for attachment level gain (DH 0.7 mm; SRP 0.8 mm) and probing depth reduction (DH 1.3 mm; SRP 1.1 mm). Percentage of sites showing ≥2 mm attachment level gain at month 9 was 24.7% in the DH group and 21.2% in the SRP group. Thirty‐nine percent (39%) of DH sites and 38% of SRP sites showed ≥2 mm probing depth reduction. When treated sides of the dentition were compared to untreated sides, DH showed a difference in disease activity (≥2 mm attachment loss) from 19.3% (untreated) to 7.2% (treated); and SRP from 14.3% (untreated) to 8.1% (treated). Conclusions: Results show that both DH without concomitant mechanical instrumentation and SRP were equally effective as SPT in this patient group over the 9‐month study period. J Periodontol 2000;71:22‐30.