Composite glandular–endocrine cell carcinoma of the common bile duct

A rare case of composite glandular–endocrine cell carcinoma of the common bile duct is presented. Histologically, this tumor consisted of adenocarcinoma and small‐cell neuroendocrine carcinoma, with a transition between the two components. The two distinct areas of the tumor were immunohistochemical...

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Bibliographic Details
Published in:Pathology international 2001-06, Vol.51 (6), p.487-490
Main Authors: Edakuni, Genichiro, Sasatomi, Eizaburo, Satoh, Toshimi, Tokunaga, Osamu, Miyazaki, Kohji
Format: Article
Language:English
Subjects:
adenocarcinoma
Adenocarcinoma - chemistry
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Aged
Aged, 80 and over
Bile Duct Neoplasms - chemistry
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Carcinoma, Neuroendocrine - chemistry
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - secondary
Carcinoma, Neuroendocrine - surgery
Cell Division
Cholangiography
common bile duct
composite carcinoma
endocrine cell carcinoma
Female
Humans
Immunoenzyme Techniques
Ki-67 Antigen - analysis
Ki‐67
Lymph Nodes - pathology
Neoplasm Invasiveness - pathology
Neoplasms, Multiple Primary - chemistry
Neoplasms, Multiple Primary - pathology
Neoplasms, Multiple Primary - surgery
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Summary:A rare case of composite glandular–endocrine cell carcinoma of the common bile duct is presented. Histologically, this tumor consisted of adenocarcinoma and small‐cell neuroendocrine carcinoma, with a transition between the two components. The two distinct areas of the tumor were immunohistochemically different, whereas the transitional zone exhibited characteristics of both areas. These features suggest that the tumor arose from a multipotential stem cell. Although it has been reported that the presence of neuroendocrine differentiation in carcinomas indicates a poor prognosis, the patient in the present case was well at the time of writing this report. This may be due to the fact that adenocarcinoma, which characteristically has a low proliferative activity, constituted the majority of the tumor.
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1440-1827.2001.01227.x