Ethambutol analogues as potential antimycobacterial agents

A range of new ethambutol analogues was synthesised and their inhibitory potencies were probed with Mycobacterium smegmatis. Interestingly, apparently even minor deviation from the structure of the parent compound resulted in reduced antimycobacterial activity. A range of symmetrical as well as unsy...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2001-07, Vol.11 (13), p.1679-1681
Main Authors: Häusler, Herwig, Kawakami, R.Pamela, Mlaker, Eva, Severn, Wayne B., Stütz, Arnold E.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
Biological and medical sciences
Ethambutol - analogs & derivatives
Ethambutol - chemistry
Ethambutol - pharmacology
Medical sciences
Microbial Sensitivity Tests
Mycobacterium smegmatis - drug effects
Pharmacology. Drug treatments
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A range of new ethambutol analogues was synthesised and their inhibitory potencies were probed with Mycobacterium smegmatis. Interestingly, apparently even minor deviation from the structure of the parent compound resulted in reduced antimycobacterial activity. A range of symmetrical as well as unsymmetrical ethambutol derivatives was prepared and inhibitory properties were screened against Mycobacterium smegmatis.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00258-X