New cytotoxic agents, BE-54238A and B, produced by a streptomycete

New cytotoxic substances, designated BE-54238A and B, were isolated from the culture broth of Streptomyces sp. A54238. The active principles were extracted from the mycelium by methanol and purified by Diaion HP-20 and Sephadex LH-20 column chromatographies. BE-54238A and B exhibited cytotoxic activ...

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Bibliographic Details
Published in:Journal of antibiotics 2000-01, Vol.53 (1), p.26-32
Main Authors: TSUKAMOTO, M, NAKAJIMA, S, MUROOKA, K, HIRAYAMA, M, HIRANO, K, YOSHIDA, S, KOJIRI, K, SUDA, H
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - therapeutic use
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic agents
Applied microbiology
BE-54238A
BE-54238B
Biological and medical sciences
Chemotherapic agents
Fermentation
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Leukemia P388 - drug therapy
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Microbiology
Molecular Structure
Pharmacology. Drug treatments
Pyrrolizidine Alkaloids - chemistry
Pyrrolizidine Alkaloids - isolation & purification
Pyrrolizidine Alkaloids - therapeutic use
Streptomyces
Structure-Activity Relationship
Tumor Cells, Cultured - drug effects
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Description
Summary:New cytotoxic substances, designated BE-54238A and B, were isolated from the culture broth of Streptomyces sp. A54238. The active principles were extracted from the mycelium by methanol and purified by Diaion HP-20 and Sephadex LH-20 column chromatographies. BE-54238A and B exhibited cytotoxic activity against murine and human tumor cell lines.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.26