Thalibealine, a Novel Tetrahydroprotoberberine−Aporphine Dimeric Alkaloid from Thalictrum wangii

A novel tetrahydroprotoberberine−aporphine dimeric alkaloid, (−)-thalibealine (1), was isolated from the roots of Thalictrum wangiii, and its structure established via spectroscopic analysis. Three other alkaloids were isolated, including the benzyltetrahydroisoquinoline−aporphine dimer (+)-thalmela...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-06, Vol.64 (6), p.819-822
Main Authors: Al-Howiriny, Tawfeq A, Zemaitis, Michael A, Gao, Cong-yuan, Hadden, Chad E, Martin, Gary E, Lin, Fu-tyan, Schiff, Paul L
Format: Article
Language:English
Subjects:
Berberine Alkaloids - chemistry
Biological and medical sciences
China
Chromatography, Thin Layer
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Roots - chemistry
Plants, Medicinal - chemistry
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
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Summary:A novel tetrahydroprotoberberine−aporphine dimeric alkaloid, (−)-thalibealine (1), was isolated from the roots of Thalictrum wangiii, and its structure established via spectroscopic analysis. Three other alkaloids were isolated, including the benzyltetrahydroisoquinoline−aporphine dimer (+)-thalmelatidine, the aporphine (+)-magnoflorine, and the protoberberine berberine. This is the first reported isolation of a tetrahydroprotoberberine−aporphine dimer from nature, as well as the first reported isolation of constituents from Thalictrum wangii.
ISSN:0163-3864
1520-6025
DOI:10.1021/np010095y