Increased levels of tPA antigen and tPA/PAI‐1 complex in myotonic dystrophy

. Johansson Å, Boman K, Cederquist K, Forsberg H, Olsson T (Umeå University Hospital, Umeå, Skellefteå County Hospital, Skellefteå, and Boden Hospital, Boden, Sweden). Increased levels of tPA antigen and tPA/PAI‐1 complex in myotonic dystrophy. J Intern Med 2001; 249: 503–510. Objective. To assess t...

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Published in:Journal of internal medicine 2001-06, Vol.249 (6), p.503-510
Main Authors: Johansson, Å., Boman, K., Cederquist, K., Forsberg, H., Olsson, T.
Format: Article
Language:English
Subjects:
Adult
Antigens - blood
Biological and medical sciences
Body Composition
Case-Control Studies
dystrophia myotonica
Electric Impedance
Enzyme-Linked Immunosorbent Assay
Female
fibrinolysis
Humans
Insulin - blood
Investigative techniques, diagnostic techniques (general aspects)
lipids
Lipids - blood
Male
Medical sciences
myotonic dystrophy
Myotonic Dystrophy - blood
Osteoarticular system. Muscles
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Plasminogen Activator Inhibitor 1 - blood
Regression Analysis
Statistics, Nonparametric
Tissue Plasminogen Activator - blood
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Summary:. Johansson Å, Boman K, Cederquist K, Forsberg H, Olsson T (Umeå University Hospital, Umeå, Skellefteå County Hospital, Skellefteå, and Boden Hospital, Boden, Sweden). Increased levels of tPA antigen and tPA/PAI‐1 complex in myotonic dystrophy. J Intern Med 2001; 249: 503–510. Objective. To assess the fibrinolytic system in myotonic dystrophy (DM1), a disease connected to features of the metabolic syndrome, including a prominent insulin resistance, increased body fat mass, and hypertriglyceridaemia. We hypothesized that abnormalities in the fibrinolytic system are linked to metabolic dysfunction in DM1. Design. Circulating morning levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor type 1 (PAI‐1) antigens, tPA/PAI‐1 complex, lipids and insulin were determined. Genetic analyses, including calculation of allele size, were performed in all patients. Body fat mass was estimated with bioelectrical impedance analysis. Setting. Out‐patient clinic in collaboration with Umeå University Hospital. Subjects. A total of 42 otherwise healthy patients with DM1 (22 men, 20 women; median age 41.5 years) and 50 controls (27 men, 23 women; median age 42.0 years). Main outcome measures. The tPA and PAI‐1 antigens, tPA/PAI‐1 complex, blood lipids and body fat mass. Results. The tPA antigen and tPA/PAI‐1 complex levels were significantly increased in DM1 patients (P 
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.2001.00832.x