The effects of oral melatonin on the autonomic function in healthy subjects

We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The...

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Bibliographic Details
Published in:Psychiatry and clinical neurosciences 2001-06, Vol.55 (3), p.299-300
Main Authors: Kitajima, Tsuyoshi, Kanbayashi, Takashi, Saitoh, Yasushi, Ogawa, Yuriko, Sugiyama, Tomonari, Kaneko, Yoshihiko, Sasaki, Yoshiko, Aizawa, Rika, Shimisu, Tetsuo
Format: Article
Language:English
Subjects:
Administration, Oral
autonomic function
baroreflex
Baroreflex - drug effects
Blood Pressure - drug effects
Electroencephalography
healthy male
Heart Rate - drug effects
Heart Rate - physiology
human
Humans
hypotensive effect
Male
melatonin
Melatonin - administration & dosage
Melatonin - blood
Melatonin - pharmacology
muscle sympathetic nerve activity
Peroneal Nerve - drug effects
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Summary:We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.
ISSN:1323-1316
1440-1819
DOI:10.1046/j.1440-1819.2001.00866.x