Intravenous leiomyomatosis of the uterus with multiple pulmonary metastases associated with large bullae‐like cyst formation

We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae‐like cystic change. A 53‐year‐old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of...

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Bibliographic Details
Published in:Pathology international 2001-05, Vol.51 (5), p.396-401
Main Authors: Matsumoto, Koshi, Yamamoto, Taiichi, Hisayoshi, Takao, Asano, Goro
Format: Article
Language:English
Subjects:
Actins - analysis
Apoproteins - analysis
Cysts - pathology
Female
fibroleiomyomatous hamartoma
Humans
intravenous leiomyomatosis
Ki-67 Antigen - analysis
Leiomyomatosis - chemistry
Leiomyomatosis - diagnostic imaging
Leiomyomatosis - pathology
Leiomyomatosis - surgery
Lung Neoplasms - chemistry
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - secondary
Lung Neoplasms - surgery
metastasizing leiomyoma
Middle Aged
Mucin-1 - analysis
Neoplasm Invasiveness
Proliferating Cell Nuclear Antigen - analysis
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactants - analysis
Radiography, Thoracic
Receptors, Estrogen - analysis
Receptors, Progesterone
Tomography, X-Ray Computed
Uterine Neoplasms - chemistry
Uterine Neoplasms - diagnostic imaging
Uterine Neoplasms - pathology
Uterine Neoplasms - surgery
Uterus - blood supply
Uterus - pathology
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Description
Summary:We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae‐like cystic change. A 53‐year‐old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of several large bullae, a subsequent extirpation of the pulmonary nodules was performed, and a pathological examination showed multiple leiomyomatous nodules with occasional cystic change. A review of the previous slides of the uterus and immunohistochemical analysis of the proliferating ability using anti‐Ki‐67 and anti‐proliferating cell nuclear antigen (PCNA) antibodies were performed. Proliferating cells of the uterus had very few mitotic figures for their high cellularity, and the labeling indices of Ki‐67 and PCNA indicated very low levels in both uterine neoplasm and pulmonary nodules. From these findings, an intravenous leiomyomatosis associated with multiple pulmonary metastases was diagnosed.
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1440-1827.2001.01205.x