A very rare benign tumour in the parotid region: calcium pyrophosphate dihydrate crystal deposition disease

Calcium pyrophosphate dihydrate crystal deposition disease, exhibits several clinical manifestations, from absence of symptoms to severely destructive arthropathy or conditions simulating neoplasm, which is frequently related to the temporomandibular joint. Fifteen of the 31 reported cases of tophac...

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Bibliographic Details
Published in:Journal of laryngology and otology 2001-06, Vol.115 (6), p.504-506
Main Authors: Olin, Helle Birgitte Dahl, Pedersen, Kaj, Francis, Dorthe, Hansen, Hanne, Poulsen, Finn Willy
Format: Article
Language:English
Subjects:
(RF) Otorhinolaryngology
Biological and medical sciences
Chondrocalcinosis
Chondrocalcinosis - diagnosis
Diagnosis, Differential
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Humans
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Parotid Diseases - diagnosis
Parotid Gland
Parotid Neoplasms - diagnosis
Salivary Gland Neoplasms
Tomography, X-Ray Computed
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Calcium pyrophosphate dihydrate crystal deposition disease, exhibits several clinical manifestations, from absence of symptoms to severely destructive arthropathy or conditions simulating neoplasm, which is frequently related to the temporomandibular joint. Fifteen of the 31 reported cases of tophaceous pseudogout were found in the head and neck region. A patient presented with a parotid swelling, which initially was suspected to be malignant because of the following findings: radiodensity, progression into the joint, osseous destruction of the major ala of the sphenoid and a fine needle aspirate with crystals, osteoblasts, megakaryocytes and irregular cells of varying size. At surgery there was found a tumour consisting of a white, firm gritty material. It progressed to the skull base where material had to be left, because of the presence of the nerves and vessels. A frozen specimen was reported to be benign. Histological examination showed inflammatory cells, macrophages, a chondroid material with embedded metaplastic chondroid cells and giant cells of foreign body type. Crystal examination of X-ray diffraction revealed calcium pyrophosphate dihydrate.
ISSN:0022-2151
1748-5460
DOI:10.1258/0022215011908063