Atypical Cilia in the Bronchiolar Epithelium of Pigs Experimentally Infected with Hog Cholera Virus

To study the effect of hog cholera virus on the epithelial cells of the bronchiolar mucosa, 12 pigs were inoculated with a highly virulent strain. Immunohistochemical and ultrastructural examination of the ciliated epithelial cells demonstrated an increase in the number of atypical cilia. The latter...

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Bibliographic Details
Published in:Journal of comparative pathology 2001-01, Vol.124 (1), p.29-35
Main Authors: Carrasco, L., Ruiz-Villamor, E., Gómez-Villamandos, J.C., Bautista, M.J., Nuñez, A., Quezada, M., Sierra, M.A.
Format: Article
Language:English
Subjects:
Animals
Bronchi - ultrastructure
Bronchi - virology
Cilia - ultrastructure
Classical Swine Fever - pathology
Classical swine fever virus - immunology
Classical swine fever virus - physiology
Classical swine fever virus - ultrastructure
Epithelium - ultrastructure
Epithelium - virology
Female
Immunoenzyme Techniques
Male
Microscopy, Electron
Respiratory Mucosa - ultrastructure
Respiratory Mucosa - virology
Swine
Viral Envelope Proteins - analysis
Virus Replication
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Summary:To study the effect of hog cholera virus on the epithelial cells of the bronchiolar mucosa, 12 pigs were inoculated with a highly virulent strain. Immunohistochemical and ultrastructural examination of the ciliated epithelial cells demonstrated an increase in the number of atypical cilia. The latter showed alterations in the microtubular pattern, possibly resulting from viral interference with the normal metabolism of the epithelial cells.
ISSN:0021-9975
1532-3129
DOI:10.1053/jcpa.2000.0424