Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance

A variety of human cancers become resistant or are intrinsically resistant to treatment with conventional drug therapies. This phenomenon is due in large part to the overexpression of a 170 kDa plasma membrane ATP-dependent pump known as the multidrug resistance transporter or P-glycoprotein. P-glyc...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2001-06, Vol.12 (3), p.247-256
Main Author: Hrycyna, Christine A
Format: Article
Language:English
Subjects:
ABC superfamily / chemotherapy / P-glycoprotein / multidrug resistance / mutational analysis
Animals
ATP Binding Cassette Transporter, Sub-Family B - chemistry
ATP Binding Cassette Transporter, Sub-Family B - genetics
ATP Binding Cassette Transporter, Sub-Family B - metabolism
Drug Resistance, Multiple
Humans
Mammals
Mutation
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Summary:A variety of human cancers become resistant or are intrinsically resistant to treatment with conventional drug therapies. This phenomenon is due in large part to the overexpression of a 170 kDa plasma membrane ATP-dependent pump known as the multidrug resistance transporter or P-glycoprotein. P-glycoprotein is a member of the large ATP binding cassette (ABC) superfamily of membrane transporters. This review focuses on the use of structure–function analyses to elucidate further the mechanism of action of mammalian P-glycoproteins. Ultimately, a complete understanding of the mechanism is important for the development of novel strategies for the treatment of many human cancers.
ISSN:1084-9521
1096-3634
DOI:10.1006/scdb.2000.0250