Immunostimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae for inactivated rabies vaccine

Humoral and cellular immune responses were analyzed with Fuenzalida–Palacios rabies vaccine associated with pGPL-Mc, polar glycopeptidolipids extracted from Mycobacterium chelonae, aiming at its use as adjuvant. These results were compared to those obtained with BCG, a well-known immunostimulator, u...

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Bibliographic Details
Published in:Vaccine 2000-04, Vol.18 (20), p.2125-2131
Main Authors: de Souza Matos, Denise Cristina, Marcovistz, Rugimar, Neway, Tsehay, da Silva, Andrea Marques Vieira, Alves, Eloisa Nunes, Pilet, Charles
Format: Article
Language:English
Subjects:
Adjuvants
Adjuvants, Immunologic - adverse effects
Animals
Antibodies, Viral - biosynthesis
Antibodies, Viral - immunology
Antigens, Bacterial - adverse effects
Antigens, Bacterial - immunology
BCG Vaccine - immunology
Biological and medical sciences
Chemical Phenomena
Chemistry, Physical
Female
Fundamental and applied biological sciences. Psychology
Glycopeptides - adverse effects
Glycopeptides - immunology
glycopeptidolipids
Humans
Hypersensitivity, Delayed - etiology
Immune responses
Immunity, Cellular
Interferons - biosynthesis
Lymphocyte Activation - immunology
Mice
Mice, Inbred BALB C
Microbiology
Mycobacterium chelonae
Mycobacterium chelonae - immunology
Neutralization Tests
Rabies vaccine
Rabies Vaccines - adverse effects
Rabies Vaccines - immunology
rabies virus
Rabies virus - immunology
Safety
Spleen - immunology
Thymus Gland - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Virology
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Summary:Humoral and cellular immune responses were analyzed with Fuenzalida–Palacios rabies vaccine associated with pGPL-Mc, polar glycopeptidolipids extracted from Mycobacterium chelonae, aiming at its use as adjuvant. These results were compared to those obtained with BCG, a well-known immunostimulator, under the same conditions. Rabies vaccine plus pGPL-Mc (2.5 mg/kg) induced a significant increase in serum neutralizing activity, in vitro lymphocyte proliferation (spontaneous, specific and mitogen stimulation) and delayed type hypersensibility. In addition, pGPL-Mc, as well as BCG, enhanced the vaccine potency. Our results support further studies to encourage the use of pGPL-Mc as an immunostimulator of veterinary vaccines, before consideration for human vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(99)00544-7