Variations in prognostic factors in primary breast cancer throughout the menstrual cycle

Aims: We investigated whether menstrual cycle dependent variations in prognostic factors are detectable in malignant breast tissue. Methods: Since 1977 the Danish Breast Cancer Cooperative Group has collected population-based information about primary clinical data, treatment regimens and follow-up...

Full description

Saved in:
Bibliographic Details
Published in:European journal of surgical oncology 2000-02, Vol.26 (1), p.11-16
Main Authors: Kroman, N, Thorpe, SM, Wohlfahrt, J, Andersen, KW, Mouridsen, HT
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
breast cancer
Breast Neoplasms - chemistry
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Denmark
Female
Gynecology. Andrology. Obstetrics
Humans
Lymphatic Metastasis
Mammary gland diseases
Medical sciences
Menstrual Cycle
Middle Aged
Mitotic Index
oestrogen receptor
Predictive Value of Tests
progesterone receptor
Prognosis
prognostic factors
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims: We investigated whether menstrual cycle dependent variations in prognostic factors are detectable in malignant breast tissue. Methods: Since 1977 the Danish Breast Cancer Cooperative Group has collected population-based information about primary clinical data, treatment regimens and follow-up status on Danish women with breast cancer. Information about last menstrual periods prior to surgery was obtained from files recorded at the time of admission for primary surgery. Included in this study were 1060 patients self-reported to be regularly menstruating and with a menstrual period within 6 weeks of surgery and who were operated in a single-step procedure. None of the patients were current users of exogenous hormones at the time of surgery. Variations of prognostic factors throughout the menstrual cycle were evaluated. Results: Overall, no significant correlation between endogenous hormone fluctuations and oestrogen receptor (ER) status and progesterone receptor (PgR) status were found. Furthermore, we observed no cycle-dependent variation for mitotic index, lymph node involvement or tumour size. Conclusions: The classical prognostic factors in breast cancer did not differ significantly throughout the menstrual cycle in the present study.
ISSN:0748-7983
1532-2157
DOI:10.1053/ejso.1999.0732