Secondary amines as new pharmacophores for macrofilaricidal drug design

Several secondary amines exhibit promising macrofilaricidal response in vivo through oral route of administration against Acanthocheilonema viteae in which N-hexylcyclohexylamine (1) shows 100% macrofilaricidal activity while a tertiary amine such as 9 elicits predominantly microfilaricidal (93%) re...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2000-02, Vol.10 (4), p.313-314
Main Authors: SRIVASTAVA, S. K, CHAUHAN, P. M. S, BHADURI, A. P, MURTHY, P. K, CHATTERJEE, R. K
Format: Article
Language:English
Subjects:
Amines - therapeutic use
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antinematodal Agents - chemistry
Antinematodal Agents - therapeutic use
Antiparasitic agents
Biological and medical sciences
Cyclohexylamines - therapeutic use
Dipetalonema - drug effects
Drug Design
Female
Filariasis - drug therapy
Filaricides - chemistry
Filaricides - therapeutic use
Male
Medical sciences
Muridae - parasitology
Pharmacology. Drug treatments
Structure-Activity Relationship
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Summary:Several secondary amines exhibit promising macrofilaricidal response in vivo through oral route of administration against Acanthocheilonema viteae in which N-hexylcyclohexylamine (1) shows 100% macrofilaricidal activity while a tertiary amine such as 9 elicits predominantly microfilaricidal (93%) response.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00687-3