Comparative in vitro activity of gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin and trovafloxacin against 4151 Gram-negative and Gram-positive organisms

Gatifloxacin, grepafloxacin, moxifloxacin and trovafloxacin are fluoroquinolones with enhanced Gram-positive activity while retaining broad-spectrum activity against Gram-negative pathogens. Levofloxacin and ciprofloxacin are older quinolones with broad activity against Gram-negative pathogens and b...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2000-02, Vol.14 (1), p.45-50
Main Authors: Blondeau, J.M., Laskowski, R., Bjarnason, J., Stewart, C.
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Aza Compounds
Biological and medical sciences
Drug Resistance, Microbial
Fluoroquinolones
Gram-negative
Gram-Negative Bacteria - drug effects
Gram-Negative Bacterial Infections - microbiology
Gram-positive
Gram-Positive Bacteria - drug effects
Gram-Positive Bacterial Infections - microbiology
Humans
Levofloxacin
Medical sciences
Microbial Sensitivity Tests
Naphthyridines - pharmacology
Ofloxacin - pharmacology
Pharmacology. Drug treatments
Piperazines - pharmacology
Pseudomonas aeruginosa
Quinolines
Staphylococcus aureus
Streptococcus agalactiae
Streptococcus pneumoniae
Streptococcus pyogenes
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Summary:Gatifloxacin, grepafloxacin, moxifloxacin and trovafloxacin are fluoroquinolones with enhanced Gram-positive activity while retaining broad-spectrum activity against Gram-negative pathogens. Levofloxacin and ciprofloxacin are older quinolones with broad activity against Gram-negative pathogens and borderline activity against some Gram-positive organisms. We compared the in vitro activity of these compounds against 4151 Gram-negative and -positive organisms. Gatifloxacin, grepafloxacin, moxifloxacin and trovafloxacin were highly active against penicillin sensitive and resistant Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus agalactiae. Ciprofloxacin and levofloxacin were active but less potent. All compounds were highly active (overall) against Gram-negative pathogens with ciprofloxacin being the most active agent against Pseudomonas aeruginosa. Our data indicate that the advanced fluoroquinolones will be important compounds for treating infections caused by Gram-positive and Gram-negative pathogens.
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(99)00143-0