Learning-related interpositus activity is conserved across species as studied during eyeblink conditioning in the rat

Single-unit activity was monitored in the interpositus nucleus of the cerebellum during standard delay conditioning of the eyeblink response in freely-moving rats. The rats were implanted with recording electrodes in the interpositus nucleus then received paired presentations of a tone-conditioned s...

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Bibliographic Details
Published in:Brain research 2001-06, Vol.905 (1), p.171-177
Main Authors: Rogers, Ronald F, Britton, Gabrielle B, Steinmetz, Joseph E
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Anatomical correlates of behavior
Animals
Behavior, Animal - physiology
Behavioral psychophysiology
Biological and medical sciences
Cerebellar Nuclei - cytology
Cerebellar Nuclei - physiology
Cerebellum
Classical conditioning
Conditioning, Eyelid - physiology
Eyelid
Fundamental and applied biological sciences. Psychology
Interpositus nucleus
Learning - physiology
Microelectrodes
Neurons - cytology
Neurons - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rabbits
Rat
Rats
Rats, Sprague-Dawley
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Summary:Single-unit activity was monitored in the interpositus nucleus of the cerebellum during standard delay conditioning of the eyeblink response in freely-moving rats. The rats were implanted with recording electrodes in the interpositus nucleus then received paired presentations of a tone-conditioned stimulus (CS) and eye-shock unconditioned stimulus during acquisition training. The acquisition training was followed by CS-alone extinction training. Learning-related activity in the interpositus nucleus developed over the course of acquisition training and then activity returned to baseline levels during subsequent extinction training. These findings are consistent with rabbit studies that have demonstrated similar changes in neuronal activity in the interpositus nucleus over the course of acquisition and extinction of the eyeblink response, thus providing strong evidence for the generality of the neural substrates of eyeblink conditioning across species.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02532-X