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False positive serum biochemical screening and subsequent fetal loss in women less than 35 years of age
Objective To examine the fetal loss rate in women younger than 35 years of age following a false positive serum biochemical screening. Design Retrospective analysis of case records between 1991 and 1998. Setting Fetal medicine unit of a large teaching hospital. Population Four hundred and fifty‐six...
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| Published in: | BJOG : an international journal of obstetrics and gynaecology 2001-06, Vol.108 (6), p.589-593 |
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| cites | cdi_FETCH-LOGICAL-c3257-6eb5c04b116f3195259e30d2ef70a3f5323c7df074ba5895fad52a197e28d7c23 |
| container_end_page | 593 |
| container_issue | 6 |
| container_start_page | 589 |
| container_title | BJOG : an international journal of obstetrics and gynaecology |
| container_volume | 108 |
| creator | Antsaklis, Aris J. Papantoniou, Nikolaos E. Daskalakis, George J. Mesogitis, Spyros A. Kitmirides, Stylianos J. Michalas, Stylianos S. |
| description | Objective
To examine the fetal loss rate in women younger than 35 years of age following a false positive serum biochemical screening.
Design
Retrospective analysis of case records between 1991 and 1998.
Setting
Fetal medicine unit of a large teaching hospital.
Population
Four hundred and fifty‐six women with singleton pregnancies and false positive serum biochemical screening for Down's Syndrome (study group). Nine hundred and twelve matched controls with true negative serum biochemical screening (control group).
Methods
Women of both groups had a second trimester serum screening for Down's Syndrome using alpha fetoprotein, human chorionic gonadotrophin (hCG) and unconjugated oestriol (uE3); and they also underwent genetic amniocentesis.
Results
The overall fetal loss rate in the study group was 5.3% (24/456), compared with 1.65% (15/912) in the control group RR 3.2, 95% CI 1.7‐5.99; P |
| doi_str_mv | 10.1111/j.1471-0528.2001.00137.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70966215</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70966215</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3257-6eb5c04b116f3195259e30d2ef70a3f5323c7df074ba5895fad52a197e28d7c23</originalsourceid><addsrcrecordid>eNqNkEtP9CAUhonReP8LhoVx18plKG3iRs3nLSZudE0oPYxMWjpC--n8e6kzUZeSEA7hObzwIIQpyWka54ucziTNiGBlzgiheZpc5h9baP_7YPurJhnhrNxDBzEuElQwwnfRHqUzVpQV20fzG91GwMs-usH9BxwhjB2uXW9eoXNGtziaAOCdn2PtGxzHOsLbCH7AFoZ03PYxYufxe9-Bxy2k3fCqPeYCr0CHiHuL9RyO0I6dko436yF6ufn3fH2XPT7d3l9fPmaGMyGzAmphyKymtLCcVoKJCjhpGFhJNLeCM25kY4mc1VqUlbC6EUzTSgIrG2kYP0Rn63uXoU_PjIPqXDTQttpDP0YlSVUUjIoElmvQhPSDAFYtg-t0WClK1CRZLdTkUk0u1SRZfUlWH6n1ZJMx1h00P40bqwk43QA6JoU2aG9c_BXAWEmqhF2ssXfXwurP-erq4SkV_BPnUJcZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70966215</pqid></control><display><type>article</type><title>False positive serum biochemical screening and subsequent fetal loss in women less than 35 years of age</title><source>Wiley</source><creator>Antsaklis, Aris J. ; Papantoniou, Nikolaos E. ; Daskalakis, George J. ; Mesogitis, Spyros A. ; Kitmirides, Stylianos J. ; Michalas, Stylianos S.</creator><creatorcontrib>Antsaklis, Aris J. ; Papantoniou, Nikolaos E. ; Daskalakis, George J. ; Mesogitis, Spyros A. ; Kitmirides, Stylianos J. ; Michalas, Stylianos S.</creatorcontrib><description>Objective
To examine the fetal loss rate in women younger than 35 years of age following a false positive serum biochemical screening.
Design
Retrospective analysis of case records between 1991 and 1998.
Setting
Fetal medicine unit of a large teaching hospital.
Population
Four hundred and fifty‐six women with singleton pregnancies and false positive serum biochemical screening for Down's Syndrome (study group). Nine hundred and twelve matched controls with true negative serum biochemical screening (control group).
Methods
Women of both groups had a second trimester serum screening for Down's Syndrome using alpha fetoprotein, human chorionic gonadotrophin (hCG) and unconjugated oestriol (uE3); and they also underwent genetic amniocentesis.
Results
The overall fetal loss rate in the study group was 5.3% (24/456), compared with 1.65% (15/912) in the control group RR 3.2, 95% CI 1.7‐5.99; P<0.001). The majority of fetal losses in the study group occurred after 28 weeks, while in the controls this happened between 24 and 28 weeks of gestation.
Conclusions
A false positive serum biochemical screening in women under 35 years of age is associated with a threefold increased risk of subsequent fetal loss. However, most of fetal losses in this group occurred after 28 weeks, indicating that intensive antepartum fetal surveillance could improve the perinatal outcome.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2001.00137.x</identifier><identifier>PMID: 11426892</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; alpha-Fetoproteins - analysis ; Biological and medical sciences ; Biomarkers - blood ; Chorionic Gonadotropin - blood ; Diseases of mother, fetus and pregnancy ; Down Syndrome - diagnosis ; Estradiol - blood ; False Positive Reactions ; Female ; Fetal Death - blood ; Fetal Death - prevention & control ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Pregnancy ; Pregnancy Outcome ; Pregnancy Trimester, Second ; Pregnancy. Fetus. Placenta ; Prenatal Diagnosis - methods ; Prenatal Diagnosis - standards ; Retrospective Studies</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2001-06, Vol.108 (6), p.589-593</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3257-6eb5c04b116f3195259e30d2ef70a3f5323c7df074ba5895fad52a197e28d7c23</citedby><cites>FETCH-LOGICAL-c3257-6eb5c04b116f3195259e30d2ef70a3f5323c7df074ba5895fad52a197e28d7c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1022809$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11426892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antsaklis, Aris J.</creatorcontrib><creatorcontrib>Papantoniou, Nikolaos E.</creatorcontrib><creatorcontrib>Daskalakis, George J.</creatorcontrib><creatorcontrib>Mesogitis, Spyros A.</creatorcontrib><creatorcontrib>Kitmirides, Stylianos J.</creatorcontrib><creatorcontrib>Michalas, Stylianos S.</creatorcontrib><title>False positive serum biochemical screening and subsequent fetal loss in women less than 35 years of age</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective
To examine the fetal loss rate in women younger than 35 years of age following a false positive serum biochemical screening.
Design
Retrospective analysis of case records between 1991 and 1998.
Setting
Fetal medicine unit of a large teaching hospital.
Population
Four hundred and fifty‐six women with singleton pregnancies and false positive serum biochemical screening for Down's Syndrome (study group). Nine hundred and twelve matched controls with true negative serum biochemical screening (control group).
Methods
Women of both groups had a second trimester serum screening for Down's Syndrome using alpha fetoprotein, human chorionic gonadotrophin (hCG) and unconjugated oestriol (uE3); and they also underwent genetic amniocentesis.
Results
The overall fetal loss rate in the study group was 5.3% (24/456), compared with 1.65% (15/912) in the control group RR 3.2, 95% CI 1.7‐5.99; P<0.001). The majority of fetal losses in the study group occurred after 28 weeks, while in the controls this happened between 24 and 28 weeks of gestation.
Conclusions
A false positive serum biochemical screening in women under 35 years of age is associated with a threefold increased risk of subsequent fetal loss. However, most of fetal losses in this group occurred after 28 weeks, indicating that intensive antepartum fetal surveillance could improve the perinatal outcome.</description><subject>Adult</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Down Syndrome - diagnosis</subject><subject>Estradiol - blood</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Fetal Death - blood</subject><subject>Fetal Death - prevention & control</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal Diagnosis - methods</subject><subject>Prenatal Diagnosis - standards</subject><subject>Retrospective Studies</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqNkEtP9CAUhonReP8LhoVx18plKG3iRs3nLSZudE0oPYxMWjpC--n8e6kzUZeSEA7hObzwIIQpyWka54ucziTNiGBlzgiheZpc5h9baP_7YPurJhnhrNxDBzEuElQwwnfRHqUzVpQV20fzG91GwMs-usH9BxwhjB2uXW9eoXNGtziaAOCdn2PtGxzHOsLbCH7AFoZ03PYxYufxe9-Bxy2k3fCqPeYCr0CHiHuL9RyO0I6dko436yF6ufn3fH2XPT7d3l9fPmaGMyGzAmphyKymtLCcVoKJCjhpGFhJNLeCM25kY4mc1VqUlbC6EUzTSgIrG2kYP0Rn63uXoU_PjIPqXDTQttpDP0YlSVUUjIoElmvQhPSDAFYtg-t0WClK1CRZLdTkUk0u1SRZfUlWH6n1ZJMx1h00P40bqwk43QA6JoU2aG9c_BXAWEmqhF2ssXfXwurP-erq4SkV_BPnUJcZ</recordid><startdate>200106</startdate><enddate>200106</enddate><creator>Antsaklis, Aris J.</creator><creator>Papantoniou, Nikolaos E.</creator><creator>Daskalakis, George J.</creator><creator>Mesogitis, Spyros A.</creator><creator>Kitmirides, Stylianos J.</creator><creator>Michalas, Stylianos S.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200106</creationdate><title>False positive serum biochemical screening and subsequent fetal loss in women less than 35 years of age</title><author>Antsaklis, Aris J. ; Papantoniou, Nikolaos E. ; Daskalakis, George J. ; Mesogitis, Spyros A. ; Kitmirides, Stylianos J. ; Michalas, Stylianos S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3257-6eb5c04b116f3195259e30d2ef70a3f5323c7df074ba5895fad52a197e28d7c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Down Syndrome - diagnosis</topic><topic>Estradiol - blood</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Fetal Death - blood</topic><topic>Fetal Death - prevention & control</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal Diagnosis - methods</topic><topic>Prenatal Diagnosis - standards</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antsaklis, Aris J.</creatorcontrib><creatorcontrib>Papantoniou, Nikolaos E.</creatorcontrib><creatorcontrib>Daskalakis, George J.</creatorcontrib><creatorcontrib>Mesogitis, Spyros A.</creatorcontrib><creatorcontrib>Kitmirides, Stylianos J.</creatorcontrib><creatorcontrib>Michalas, Stylianos S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antsaklis, Aris J.</au><au>Papantoniou, Nikolaos E.</au><au>Daskalakis, George J.</au><au>Mesogitis, Spyros A.</au><au>Kitmirides, Stylianos J.</au><au>Michalas, Stylianos S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>False positive serum biochemical screening and subsequent fetal loss in women less than 35 years of age</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2001-06</date><risdate>2001</risdate><volume>108</volume><issue>6</issue><spage>589</spage><epage>593</epage><pages>589-593</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract>Objective
To examine the fetal loss rate in women younger than 35 years of age following a false positive serum biochemical screening.
Design
Retrospective analysis of case records between 1991 and 1998.
Setting
Fetal medicine unit of a large teaching hospital.
Population
Four hundred and fifty‐six women with singleton pregnancies and false positive serum biochemical screening for Down's Syndrome (study group). Nine hundred and twelve matched controls with true negative serum biochemical screening (control group).
Methods
Women of both groups had a second trimester serum screening for Down's Syndrome using alpha fetoprotein, human chorionic gonadotrophin (hCG) and unconjugated oestriol (uE3); and they also underwent genetic amniocentesis.
Results
The overall fetal loss rate in the study group was 5.3% (24/456), compared with 1.65% (15/912) in the control group RR 3.2, 95% CI 1.7‐5.99; P<0.001). The majority of fetal losses in the study group occurred after 28 weeks, while in the controls this happened between 24 and 28 weeks of gestation.
Conclusions
A false positive serum biochemical screening in women under 35 years of age is associated with a threefold increased risk of subsequent fetal loss. However, most of fetal losses in this group occurred after 28 weeks, indicating that intensive antepartum fetal surveillance could improve the perinatal outcome.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11426892</pmid><doi>10.1111/j.1471-0528.2001.00137.x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2001-06, Vol.108 (6), p.589-593 |
| issn | 1470-0328 1471-0528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70966215 |
| source | Wiley |
| subjects | Adult alpha-Fetoproteins - analysis Biological and medical sciences Biomarkers - blood Chorionic Gonadotropin - blood Diseases of mother, fetus and pregnancy Down Syndrome - diagnosis Estradiol - blood False Positive Reactions Female Fetal Death - blood Fetal Death - prevention & control Gynecology. Andrology. Obstetrics Humans Medical sciences Pregnancy Pregnancy Outcome Pregnancy Trimester, Second Pregnancy. Fetus. Placenta Prenatal Diagnosis - methods Prenatal Diagnosis - standards Retrospective Studies |
| title | False positive serum biochemical screening and subsequent fetal loss in women less than 35 years of age |
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