Effects of lifelong ethanol consumption on drinking behavior and motor impairment of alcohol-preferring AA and alcohol-avoiding ANA rats

The effects of drinking ethanol throughout a lifetime on voluntary drinking behavior and ethanol-induced motor impairment were studied in alcohol-preferring AA (Alko, Alcohol) and alcohol-avoiding ANA (Alko, Non-Alcohol) rats of both sexes. At the age 3 months, the rats were tested for individual vo...

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2001-04, Vol.23 (3), p.157-166
Main Authors: Sarviharju, Maija, Jaatinen, Pia, Hyytiä, Petri, Hervonen, Antti, Kiianmaa, Kalervo
Format: Article
Language:English
Subjects:
Aging
Alcohol Drinking
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
Body Weight
Drinking
Eating
Energy Intake
Ethanol - administration & dosage
Ethanol - pharmacology
Female
Food Preferences
Long-term ethanol consumption
Male
Medical sciences
Motor Activity - drug effects
Motor impairment
Posture
Rats
Self Administration
Sex Characteristics
Toxicology
Voluntary ethanol drinking
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Summary:The effects of drinking ethanol throughout a lifetime on voluntary drinking behavior and ethanol-induced motor impairment were studied in alcohol-preferring AA (Alko, Alcohol) and alcohol-avoiding ANA (Alko, Non-Alcohol) rats of both sexes. At the age 3 months, the rats were tested for individual voluntary ethanol (10% vol./vol.) intake and ethanol-induced motor impairment (2 g/kg, i.p.). The rats were housed in group cages, half of them having 12% (vol./vol.) ethanol as the only source of fluid and the other half having free access to water. Food was always available for all animals. At the age of 23 months, their individual voluntary ethanol intake and ethanol-induced motor impairment were tested again. During forced drinking, the females of both strains consumed more ethanol than did the males. The ethanol consumption of the AA and ANA females and the ANA males increased significantly ( P
ISSN:0741-8329
1873-6823
DOI:10.1016/S0741-8329(01)00132-X