Clinical and histopathologic characteristics of trichrome vitiligo

The term trichrome vitiligo describes lesions that have a tan zone of varying width between normal and totally depigmented skin, which exhibits an intermediate hue. However, the pathogenesis and the histopathologic characteristics of trichrome vitiligo are unknown. Our purpose was to investigate the...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2000-04, Vol.42 (4), p.589-596
Main Authors: HANN, S.-K, KIM, Y.-S, JUNG HOAN YOO, CHUN, Y.-S
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Dermatology
Female
Humans
Male
Medical sciences
Pigmentary diseases of the skin
PUVA Therapy
Skin - pathology
Skin Pigmentation
Vitiligo - diagnosis
Vitiligo - drug therapy
Vitiligo - pathology
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Summary:The term trichrome vitiligo describes lesions that have a tan zone of varying width between normal and totally depigmented skin, which exhibits an intermediate hue. However, the pathogenesis and the histopathologic characteristics of trichrome vitiligo are unknown. Our purpose was to investigate the clinical and histopathologic characteristics and the pathogenesis of trichrome vitiligo. Four punch biopsy specimens were taken from 21 patients with trichrome vitiligo; they were from vitiliginous skin, light brown skin, perilesional normal skin, and normal skin as far as 5 cm from the nearest vitiligo spot. The sections were stained with hematoxylin-eosin; in selected cases, we performed immunohistochemical staining with S-100 protein and CD1a. Trichrome vitiligo occurred most frequently on the trunk in active vitiligo vulgaris. Focal vacuolar degeneration of the basal cell layer and mild inflammatory cell infiltration of the epidermis and dermis were more prominent in light brown skin and perilesional normal skin than in vitiliginous skin and normal skin. The number of melanocytes was decreased in light brown skin compared with perilesional normal skin (P
ISSN:0190-9622
1097-6787
DOI:10.1016/s0190-9622(00)90170-1