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Clinical and histopathologic characteristics of trichrome vitiligo
The term trichrome vitiligo describes lesions that have a tan zone of varying width between normal and totally depigmented skin, which exhibits an intermediate hue. However, the pathogenesis and the histopathologic characteristics of trichrome vitiligo are unknown. Our purpose was to investigate the...
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| Published in: | Journal of the American Academy of Dermatology 2000-04, Vol.42 (4), p.589-596 |
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| creator | HANN, S.-K KIM, Y.-S JUNG HOAN YOO CHUN, Y.-S |
| description | The term trichrome vitiligo describes lesions that have a tan zone of varying width between normal and totally depigmented skin, which exhibits an intermediate hue. However, the pathogenesis and the histopathologic characteristics of trichrome vitiligo are unknown.
Our purpose was to investigate the clinical and histopathologic characteristics and the pathogenesis of trichrome vitiligo.
Four punch biopsy specimens were taken from 21 patients with trichrome vitiligo; they were from vitiliginous skin, light brown skin, perilesional normal skin, and normal skin as far as 5 cm from the nearest vitiligo spot. The sections were stained with hematoxylin-eosin; in selected cases, we performed immunohistochemical staining with S-100 protein and CD1a.
Trichrome vitiligo occurred most frequently on the trunk in active vitiligo vulgaris. Focal vacuolar degeneration of the basal cell layer and mild inflammatory cell infiltration of the epidermis and dermis were more prominent in light brown skin and perilesional normal skin than in vitiliginous skin and normal skin. The number of melanocytes was decreased in light brown skin compared with perilesional normal skin (P |
| doi_str_mv | 10.1016/s0190-9622(00)90170-1 |
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Our purpose was to investigate the clinical and histopathologic characteristics and the pathogenesis of trichrome vitiligo.
Four punch biopsy specimens were taken from 21 patients with trichrome vitiligo; they were from vitiliginous skin, light brown skin, perilesional normal skin, and normal skin as far as 5 cm from the nearest vitiligo spot. The sections were stained with hematoxylin-eosin; in selected cases, we performed immunohistochemical staining with S-100 protein and CD1a.
Trichrome vitiligo occurred most frequently on the trunk in active vitiligo vulgaris. Focal vacuolar degeneration of the basal cell layer and mild inflammatory cell infiltration of the epidermis and dermis were more prominent in light brown skin and perilesional normal skin than in vitiliginous skin and normal skin. The number of melanocytes was decreased in light brown skin compared with perilesional normal skin (P <.05) and in vitiliginous skin compared with light brown skin (P <.05); a few melanocytes were observed even in skin affected by trichrome vitiligo. The number of Langerhans cells was increased in the epidermis of light brown skin and perilesional normal skin compared with vitiliginous and normal skin (P <.05). PUVA therapy yielded excellent repigmentation.
Trichrome vitiligo is a variant of active vitiligo. The changes of melanocytes, keratinocytes, and Langerhans cells may be involved in the pathogenesis of depigmentation in trichrome vitiligo.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/s0190-9622(00)90170-1</identifier><identifier>PMID: 10727303</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; Dermatology ; Female ; Humans ; Male ; Medical sciences ; Pigmentary diseases of the skin ; PUVA Therapy ; Skin - pathology ; Skin Pigmentation ; Vitiligo - diagnosis ; Vitiligo - drug therapy ; Vitiligo - pathology</subject><ispartof>Journal of the American Academy of Dermatology, 2000-04, Vol.42 (4), p.589-596</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-4f52fcd64c4ae1f4f0f461e4eefbeb4543f9a6fe09999fb4214a42a80b1705dc3</citedby><cites>FETCH-LOGICAL-c334t-4f52fcd64c4ae1f4f0f461e4eefbeb4543f9a6fe09999fb4214a42a80b1705dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1332473$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10727303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HANN, S.-K</creatorcontrib><creatorcontrib>KIM, Y.-S</creatorcontrib><creatorcontrib>JUNG HOAN YOO</creatorcontrib><creatorcontrib>CHUN, Y.-S</creatorcontrib><title>Clinical and histopathologic characteristics of trichrome vitiligo</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>The term trichrome vitiligo describes lesions that have a tan zone of varying width between normal and totally depigmented skin, which exhibits an intermediate hue. However, the pathogenesis and the histopathologic characteristics of trichrome vitiligo are unknown.
Our purpose was to investigate the clinical and histopathologic characteristics and the pathogenesis of trichrome vitiligo.
Four punch biopsy specimens were taken from 21 patients with trichrome vitiligo; they were from vitiliginous skin, light brown skin, perilesional normal skin, and normal skin as far as 5 cm from the nearest vitiligo spot. The sections were stained with hematoxylin-eosin; in selected cases, we performed immunohistochemical staining with S-100 protein and CD1a.
Trichrome vitiligo occurred most frequently on the trunk in active vitiligo vulgaris. Focal vacuolar degeneration of the basal cell layer and mild inflammatory cell infiltration of the epidermis and dermis were more prominent in light brown skin and perilesional normal skin than in vitiliginous skin and normal skin. The number of melanocytes was decreased in light brown skin compared with perilesional normal skin (P <.05) and in vitiliginous skin compared with light brown skin (P <.05); a few melanocytes were observed even in skin affected by trichrome vitiligo. The number of Langerhans cells was increased in the epidermis of light brown skin and perilesional normal skin compared with vitiliginous and normal skin (P <.05). PUVA therapy yielded excellent repigmentation.
Trichrome vitiligo is a variant of active vitiligo. The changes of melanocytes, keratinocytes, and Langerhans cells may be involved in the pathogenesis of depigmentation in trichrome vitiligo.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pigmentary diseases of the skin</subject><subject>PUVA Therapy</subject><subject>Skin - pathology</subject><subject>Skin Pigmentation</subject><subject>Vitiligo - diagnosis</subject><subject>Vitiligo - drug therapy</subject><subject>Vitiligo - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpNkE1LxDAQhoMo7rr6E5QeRPRQnXy02R518QsWPKjnkKbJNtI2a5IV_Pem7KLOZWB4Zob3QegUwzUGXN4EwBXkVUnIJcBVBZhDjvfQFEPF85LP-T6a_iITdBTCBwBUjPJDNMHACadAp-hu0dnBKtllcmiy1obo1jK2rnMrqzLVSi9V1D7NrQqZM1n0VrXe9Tr7stF2duWO0YGRXdAnuz5D7w_3b4unfPny-Ly4XeaKUhZzZgpiVFMyxaTGhhkwrMSaaW1qXbOCUVPJ0mioUpmaEcwkI3IOdYpWNIrO0MX27tq7z40OUfQ2KN11ctBuEwRPyYEBSWCxBZV3IXhtxNrbXvpvgUGM8sTraEaMZgSkPsoTOO2d7R5s6l43_7a2thJwvgNkSMqMl4Oy4Y-jlDBO6Q_mW3gp</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>HANN, S.-K</creator><creator>KIM, Y.-S</creator><creator>JUNG HOAN YOO</creator><creator>CHUN, Y.-S</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Clinical and histopathologic characteristics of trichrome vitiligo</title><author>HANN, S.-K ; KIM, Y.-S ; JUNG HOAN YOO ; CHUN, Y.-S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-4f52fcd64c4ae1f4f0f461e4eefbeb4543f9a6fe09999fb4214a42a80b1705dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pigmentary diseases of the skin</topic><topic>PUVA Therapy</topic><topic>Skin - pathology</topic><topic>Skin Pigmentation</topic><topic>Vitiligo - diagnosis</topic><topic>Vitiligo - drug therapy</topic><topic>Vitiligo - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HANN, S.-K</creatorcontrib><creatorcontrib>KIM, Y.-S</creatorcontrib><creatorcontrib>JUNG HOAN YOO</creatorcontrib><creatorcontrib>CHUN, Y.-S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HANN, S.-K</au><au>KIM, Y.-S</au><au>JUNG HOAN YOO</au><au>CHUN, Y.-S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and histopathologic characteristics of trichrome vitiligo</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>42</volume><issue>4</issue><spage>589</spage><epage>596</epage><pages>589-596</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>The term trichrome vitiligo describes lesions that have a tan zone of varying width between normal and totally depigmented skin, which exhibits an intermediate hue. However, the pathogenesis and the histopathologic characteristics of trichrome vitiligo are unknown.
Our purpose was to investigate the clinical and histopathologic characteristics and the pathogenesis of trichrome vitiligo.
Four punch biopsy specimens were taken from 21 patients with trichrome vitiligo; they were from vitiliginous skin, light brown skin, perilesional normal skin, and normal skin as far as 5 cm from the nearest vitiligo spot. The sections were stained with hematoxylin-eosin; in selected cases, we performed immunohistochemical staining with S-100 protein and CD1a.
Trichrome vitiligo occurred most frequently on the trunk in active vitiligo vulgaris. Focal vacuolar degeneration of the basal cell layer and mild inflammatory cell infiltration of the epidermis and dermis were more prominent in light brown skin and perilesional normal skin than in vitiliginous skin and normal skin. The number of melanocytes was decreased in light brown skin compared with perilesional normal skin (P <.05) and in vitiliginous skin compared with light brown skin (P <.05); a few melanocytes were observed even in skin affected by trichrome vitiligo. The number of Langerhans cells was increased in the epidermis of light brown skin and perilesional normal skin compared with vitiliginous and normal skin (P <.05). PUVA therapy yielded excellent repigmentation.
Trichrome vitiligo is a variant of active vitiligo. The changes of melanocytes, keratinocytes, and Langerhans cells may be involved in the pathogenesis of depigmentation in trichrome vitiligo.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>10727303</pmid><doi>10.1016/s0190-9622(00)90170-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Biopsy Dermatology Female Humans Male Medical sciences Pigmentary diseases of the skin PUVA Therapy Skin - pathology Skin Pigmentation Vitiligo - diagnosis Vitiligo - drug therapy Vitiligo - pathology |
| title | Clinical and histopathologic characteristics of trichrome vitiligo |
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