Analysis of clinicopathologic prognostic factors for 157 uterine sarcomas and evaluation of a grading score validated for soft tissue sarcoma

• Published in: Cancer 2000-03, Vol.88 (6), p.1425-1431
• Main Authors: Pautier, Patricia, Genestie, Catherine, Rey, Annie, Morice, Philippe, Roche, Béatrice, Lhommé, Catherine, Haie‐Meder, Christine, Duvillard, Pierre
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Aged; Analysis of Variance; Biological and medical sciences; Cell Differentiation; clinicopathologic factors; Disease-Free Survival; Female; Female genital diseases; Follow-Up Studies; Gynecology. Andrology. Obstetrics; Humans; Leiomyosarcoma - pathology; Leiomyosarcoma - therapy; Medical sciences; Middle Aged; Mitosis; Mixed Tumor, Mullerian - pathology; Mixed Tumor, Mullerian - therapy; Multivariate Analysis; Necrosis; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Prognosis; Proportional Hazards Models; Reproducibility of Results; Retrospective Studies; sarcoma; Sarcoma - pathology; Sarcoma - secondary; Sarcoma - therapy; Sarcoma, Endometrial Stromal - pathology; Sarcoma, Endometrial Stromal - therapy; Survival Rate; Treatment Outcome; Tumors; uterine neoplasms; Uterine Neoplasms - pathology; Uterine Neoplasms - therapy; Uterus
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/(SICI)1097-0142(20000315)88:6<1425::AID-CNCR21>3.0.CO;2-3

BACKGROUND Uterine sarcomas (US) are rare and carry a poor prognosis characterized by high rates of local recurrence and metastasis. The aim of this study was to test, for what the authors believe was the first time with US, the prognostic impact of the histologic grade validated by the French Federation of Anticancer Centers (FNCLCC) for soft tissue sarcomas (STS). The grade is the sum of the scores allocated for three major histologic criteria: tumor differentiation, mitotic count, and tumor necrosis. Other histologic and clinical factors were tested as well. METHODS The study included 157 patients in whom 78 leiomyosarcomas (LMS), 52 malignant mixed müllerian tumors (MMMT), and 27 endometrial stroma sarcomas (ESS) were documented. RESULTS The median follow‐up was 54 months (range, 6–230 months). The median OS and EFS were 33 and 13 months, respectively. The FNCLCC grade validated in soft tissue sarcomas was not a prognostic factor for survival or relapse for any of the US histologic subtypes. For LMS, stage and mitotic count were the only factors that had an influence on survival and relapse. For MMMT, stage and age were the only prognostic factors, and none of the histologic criteria impacted on the outcome. For ESS, the grade defined by Norris and Taylor was an important prognostic factor, particularly for survival. CONCLUSIONS The FNCLCC grading score could not be used as a prognostic indicator for uterine sarcomas. The diagnosis of US is in itself an unfavorable prognostic factor, except when the diagnosis is low grade ESS. Cancer 2000;88:1425–31. © 2000 American Cancer Society. Uterine sarcomas, except for low grade stromal sarcomas, are associated with a poor prognosis. The grading score validated by the French Federation of Anticancer Centers for soft tissue sarcoma was not a prognostic factor in this study.