Clinicopathological factors predicting outcome after resection of mass-forming intrahepatic cholangiocarcinoma

Background: The prognosis for patients with intrahepatic cholangiocarcinoma differs according to macroscopic type. The identification of clinical and pathological features that predict outcome in patients with mass‐forming intrahepatic cholangiocarcinoma is required in order to determine optimal sur...

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Bibliographic Details
Published in:British journal of surgery 2001-07, Vol.88 (7), p.969-974
Main Authors: Uenishi, T., Hirohashi, K., Kubo, S., Yamamoto, T., Yamazaki, O., Kinoshita, H.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Bile Ducts, Intrahepatic
Biological and medical sciences
Cholangiocarcinoma - pathology
Cholangiocarcinoma - surgery
Female
Humans
Liver, biliary tract, pancreas, portal circulation, spleen
Lymph Node Excision
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Multivariate Analysis
Postoperative Complications - pathology
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Survival Analysis
Treatment Outcome
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Summary:Background: The prognosis for patients with intrahepatic cholangiocarcinoma differs according to macroscopic type. The identification of clinical and pathological features that predict outcome in patients with mass‐forming intrahepatic cholangiocarcinoma is required in order to determine optimal surgical strategies for patients with this type of tumour. Methods: The details of 35 patients with resected mass‐forming intrahepatic cholangiocarcinomas were analysed retrospectively. Univariate analysis of potential prognostic factors was performed. Results: The cumulative survival rate at 1, 3 and 5 years after operation was 58, 33 and 33 per cent respectively. Patients with stage II tumours had a better outcome than those with advanced stage tumours. By univariate analysis, lymphatic invasion, lymph node metastasis, intrahepatic satellite lesions and microscopic resection margin involvement were found to be highly significant variables and were identified as possible risk factors for a poor outcome after operation. Conclusion: When frozen‐section examination of lymph nodes reveals negative nodal metastasis, extensive anatomical hepatic resection is indicated for mass‐forming intrahepatic cholangiocarcinomas. Intraoperative frozen‐section examination of the resection margin to confirm the absence of cancer cells is recommended. © 2001 British Journal of Surgery Society Ltd
ISSN:0007-1323
1365-2168
DOI:10.1046/j.0007-1323.2001.01784.x