PF1163A and B, New Antifungal Antibiotics Produced by Penicillium sp: I. Taxonomy of Producing Strain, Fermentation, Isolation and Biological Activities

Two novel antifungal antibiotics, PF1163A and B, were isolated from the fermentation broth of Penicillium sp. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies. PF1163A and B showed potent growth inhibitory...

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Bibliographic Details
Published in:Journal of antibiotics 2000/01/25, Vol.53(1), pp.33-37
Main Authors: NOSE, HIROSHI, SEKI, ASAKO, YAGUCHI, TAKASHI, HOSOYA, AYAKO, SASAKI, TORU, HOSHIKO, SHIGERU, SHOMURA, TAKASHI
Format: Article
Language:English
Subjects:
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Applied microbiology
Biological and medical sciences
Candida albicans
Candida albicans - drug effects
Candida albicans - metabolism
Ergosterol - biosynthesis
Fermentation
Fundamental and applied biological sciences. Psychology
Humans
Macrocyclic Compounds
Medical sciences
Microbial Sensitivity Tests
Microbiology
Penicillium
PF1163A
PF1163B
Pharmacology. Drug treatments
Tumor Cells, Cultured - drug effects
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Summary:Two novel antifungal antibiotics, PF1163A and B, were isolated from the fermentation broth of Penicillium sp. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies. PF1163A and B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells. These compounds inhibited the ergosterol biosynthesis in Candida albicans.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.33