Importance of a pyrogallol-type structure in catechin compounds for apoptosis-inducing activity

Several catechin compounds were examined for their ability to induce apoptosis in human hystiocytic lymphoma U937 cells. Catechins with a pyrogallol-type structure in a B-ring induced apoptosis and a 3- O-gallate group in cis-relationship to the B ring enhanced the activity. Catechins without a pyro...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2000-02, Vol.53 (3), p.391-394
Main Authors: Saeki, Kouichi, Hayakawa, Sumio, Isemura, Mamoru, Miyase, Toshio
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Camellia sinensis
Catechin - chemistry
Catechin - pharmacology
Chemical constitution
Fundamental and applied biological sciences. Psychology
General pharmacology
Humans
Lymphoma, Large B-Cell, Diffuse - pathology
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant physiology and development
Polyphenol structure
Pyrogallol - analysis
Tea catechins
Theaceae
U937 Cells
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Summary:Several catechin compounds were examined for their ability to induce apoptosis in human hystiocytic lymphoma U937 cells. Catechins with a pyrogallol-type structure in a B-ring induced apoptosis and a 3- O-gallate group in cis-relationship to the B ring enhanced the activity. Catechins without a pyrogallol-type structure in a molecule lacked activity. These data suggest the important role of the 5′(3′)-hydroxyl group in the B-ring and that a pyrogallol-type structure in a molecule is a minimum requirement for apoptosis induction by catechin compounds.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(99)00513-0