Growth hormone as a neuronal rescue factor during recovery from CNS injury

There is growing evidence to suggest that growth hormone plays a role in the growth and development of the CNS. Specifically, growth hormone has been implicated in promoting brain growth, myelination, neuronal arborisation, glial differentiation and cognitive function. Here we investigate if growth...

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Bibliographic Details
Published in:Neuroscience 2001-01, Vol.104 (3), p.677-687
Main Authors: Scheepens, A, Sirimanne, E.S, Breier, B.H, Clark, R.G, Gluckman, P.D, Williams, C.E
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Apoptosis - physiology
Biological and medical sciences
brain
Brain - drug effects
Brain - metabolism
Brain - physiopathology
Brain Injuries - drug therapy
Brain Injuries - metabolism
Brain Injuries - physiopathology
Carrier Proteins - pharmacology
Cell Count
Cell Survival - drug effects
Cell Survival - physiology
Female
growth factor
Growth Hormone - metabolism
Growth Hormone - pharmacology
Hypoxia-Ischemia, Brain - drug therapy
Hypoxia-Ischemia, Brain - metabolism
Hypoxia-Ischemia, Brain - physiopathology
Immunohistochemistry
ischaemia
Male
Medical sciences
Nerve Growth Factors - pharmacology
Neuroglia - cytology
Neuroglia - drug effects
Neuroglia - metabolism
neuron
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Neuropharmacology
Neuroprotective agent
Neuroprotective Agents - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Wistar
Recombinant Proteins - pharmacology
Recovery of Function - drug effects
Recovery of Function - physiology
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Summary:There is growing evidence to suggest that growth hormone plays a role in the growth and development of the CNS. Specifically, growth hormone has been implicated in promoting brain growth, myelination, neuronal arborisation, glial differentiation and cognitive function. Here we investigate if growth hormone has a role in the recovery from an unilateral hypoxic–ischaemic brain injury. Using moderate (15 min hypoxia) and severe (60 min hypoxia) models of hypoxic–ischaemia in juvenile rats and standard immunohistochemical techniques, we found intense growth hormone-like immunoreactivity present within regions of cell loss by 3 days ( P
ISSN:0306-4522
1873-7544
DOI:10.1016/S0306-4522(01)00109-9