The role of SLP-76 and LAT in lymphocyte development

SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and...

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Bibliographic Details
Published in:Current Opinion in Immunology 2000-04, Vol.12 (2), p.173-178
Main Authors: Pivniouk, Vadim I, Geha, Raif S
Format: Article
Language:English
Subjects:
Adaptor proteins
Adaptor Proteins, Signal Transducing
Alleles
Allelic exclusion
Animals
Carrier Proteins - chemistry
Carrier Proteins - genetics
Carrier Proteins - physiology
Cell Differentiation
Cell Lineage
DNA Nucleotidyltransferases - metabolism
Feedback
Gene Expression Regulation, Developmental
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Hematopoiesis
Humans
ITAM-containing receptors
LAT
LAT protein
Lymphocyte Activation
Membrane Proteins
Mice
Mice, Knockout
Phenotype
Phosphoproteins - chemistry
Phosphoproteins - deficiency
Phosphoproteins - genetics
Phosphoproteins - physiology
Protein Conformation
Protein Structure, Tertiary
Receptors, Antigen, T-Cell, alpha-beta - genetics
Signal Transduction
Signaling
SLP-76
SLP-76 protein
Structure-Activity Relationship
T cell development
T-Lymphocyte Subsets - cytology
TCR
Thymus Gland - cytology
Transgenes
VDJ Recombinases
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Description
Summary:SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negative thymocytes and that SLP-76 is essential for allelic exclusion at the TCRβ locus.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(99)00068-0