High fat intake lowers hepatic fatty acid synthesis and raises fatty acid oxidation in aerobic muscle in Shetland ponies

• Published in: British journal of nutrition 2001-07, Vol.86 (1), p.31-36
• Main Authors: Geelen, Suzanne N. J., Blázquez, Cristina, Geelen, Math J. H., Sloet van Oldruitenborgh-Oosterbaan, Marianne M., Beynen, Anton C.
• Format: Article
• Language: English
• Subjects: Acetyl-CoA Carboxylase - metabolism; Animal Nutritional Physiological Phenomena; Animals; Biochemistry; Biological and medical sciences; Biopsy; Carnitine O-Palmitoyltransferase - metabolism; Citrate (si)-Synthase - metabolism; Dehydrogenases; Diet; Dietary fat; Enzymes; Equine; Fatty acid oxidation; Fatty Acid Synthases - metabolism; Fatty acids; Fatty Acids - biosynthesis; Fatty Acids - metabolism; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Glucose; Glycogen - analysis; Hepatic lipogenisis; Horses; Horses - metabolism; Human subjects; Liver - enzymology; Male; Medical research; Metabolism; Mitochondria, Liver - metabolism; Muscle fat metabolism; Muscle, Skeletal - chemistry; Muscle, Skeletal - metabolism; Muscles; Myocardium - enzymology; Nutrition research; Oils & fats; Oxidation; Oxidation-Reduction; Plasma; Soybean Oil - administration & dosage; Triglycerides - analysis; Triglycerides - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Veterinary medicine
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1079/BJN2001364

The metabolic effects of feeding soyabean oil instead of an isoenergetic amount of maize starch plus glucose were studied in ponies. Twelve adult Shetland ponies were given a control diet (15 g fat/kg DM) or a high-fat diet (118 g fat/kg DM) according to a parallel design. The diets were fed for 45 d. Plasma triacylglycerol (TAG) concentrations decreased by 55 % following fat supplementation. Fat feeding also reduced glycogen concentrations significantly by up to 65 % in masseter, gluteus and semitendinosus muscles (P