Confirmation of the prophylactic value of paromomycin in a natural outbreak of caprine cryptosporidiosis

Cryptosporidiosis is a serious enteric disease in neonatal ruminants, yet there is presently no established means of treating or preventing this infection. Paromomycin is an aminoglycoside antibiotic analogous in structure to neomycin. It has been shown to inhibit Cryptosporidium in cultures of huma...

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Bibliographic Details
Published in:Veterinary research communications 2000-02, Vol.24 (1), p.63-67
Main Authors: Johnson, E.H, Windsor, J.J, Muirhead, D.E, King, G.J, Al-Busaidy, R
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Anti-Bacterial Agents - therapeutic use
chemoprevention
cryptosporidiosis
Cryptosporidiosis - epidemiology
Cryptosporidiosis - prevention & control
Cryptosporidiosis - veterinary
Cryptosporidium
Cryptosporidium - drug effects
Cryptosporidium - growth & development
disease control
Disease Outbreaks - veterinary
disease prevention
evaluation
Feces - microbiology
Feces - parasitology
feces composition
Goat Diseases - epidemiology
Goat Diseases - parasitology
Goat Diseases - prevention & control
Goats
Intestine, Small - parasitology
Microscopy, Electron - veterinary
Microscopy, Electron, Scanning - veterinary
Microscopy, Fluorescence
mortality
necropsy
Oman
Oman - epidemiology
outbreaks
paromomycin
Paromomycin - therapeutic use
Random Allocation
symptoms
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Summary:Cryptosporidiosis is a serious enteric disease in neonatal ruminants, yet there is presently no established means of treating or preventing this infection. Paromomycin is an aminoglycoside antibiotic analogous in structure to neomycin. It has been shown to inhibit Cryptosporidium in cultures of human enterocytes and has been used to treat AIDS patients with acute cryptosporidiosis, with promising results. It has also shown promise when given therapeutically to SCID mice and piglets and when given prophylactically to experimentally or naturally infected dairy calves and kids. An acute natural outbreak of cryptosporidiosis on a large goat farm in the Sultanate of Oman resulted in the death of 242 animals ranging in age from 2 days to over 1 year. In the midst of this outbreak, we tested the prophylactic efficacy of paromomycin administered to a select group of newborn kids.
ISSN:0165-7380
1573-7446
DOI:10.1023/A:1006381522986