Expression of protease-activated receptor 1 in oral squamous cell carcinoma

Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in non-metastatic cells than in metastatic cells. Thrombin sti...

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Bibliographic Details
Published in:Cancer letters 2001-08, Vol.169 (2), p.173-180
Main Authors: Liu, Yanna, Gilcrease, Michael Z., Henderson, Ying, Yuan, Xiao H., Clayman, Gary L., Chen, Zhuo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blotting, Western
Caenorhabditis elegans Proteins
Carcinoma, Squamous Cell - metabolism
Cell Adhesion
Cell Division
Cell Line
Fibronectins - metabolism
Humans
Immunohistochemistry
Matrix metalloproteinase
Matrix Metalloproteinase 2 - biosynthesis
Matrix Metalloproteinase 9 - biosynthesis
Matrix Metalloproteinases - metabolism
Medical sciences
Metastasis
Mouth Neoplasms - metabolism
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Protease-activated receptor
Protein-Serine-Threonine Kinases - metabolism
Proteins - pharmacology
Receptor, PAR-1
Receptors, Thrombin - biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Squamous cell carcinoma
Thrombin
Thrombin - metabolism
Thrombin - pharmacology
Tumor Cells, Cultured
Tumors
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Summary:Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in non-metastatic cells than in metastatic cells. Thrombin stimulated the growth of metastatic cells, and both thrombin and thrombin receptor activation peptide (TRP) enhanced the adhesion of these cells to fibronectin, but had no effect on non-metastatic cells. Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(01)00504-3