Three New Peroxides from the Sponge Plakinastrella Species

Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide−lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-02, Vol.64 (2), p.262-264
Main Authors: Chen, Ying, Killday, K. Brian, McCarthy, Peter J, Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A, Wright, Amy E
Format: Article
Language:English
Subjects:
Animals
Aspergillus fumigatus
Biological and medical sciences
Candida albicans
Chemical control
Control
epiplakinic acid F
Fundamental and applied biological sciences. Psychology
Fungal plant pathogens
General pharmacology
Isomerism
Magnetic Resonance Spectroscopy
Marine
Medical sciences
Models, Chemical
natural products
peroxides
Peroxides - chemistry
Peroxides - isolation & purification
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytopathology. Animal pests. Plant and forest protection
Plakinastrella
plakinic acid F
plakortolide F
Porifera - chemistry
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Summary:Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide−lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 μg/mL (SDB) and 3.1 μg/mL (RPMI) for 3, and 25 μg/mL (SDB) and 6.25 μg/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 μg/mL.
ISSN:0163-3864
1520-6025
DOI:10.1021/np000368+