Haematocin, a New Antifungal Diketopiperazine Produced by Nectria haematococca Berk, et Br. (880701a-l) Causing Nectria Blight Disease on Ornamental Plants

A new antifungal diketopiperazine named haematocin was isolated from the culture broth of Nectria haematococca Berk, et Br. (880701 a-1) causing blight disease on ornamental plants, Phalaenopsis spp. and Doritanopsis spp. Its structure was established by spectroscopic methods. Haematocin inhibited t...

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Bibliographic Details
Published in:Journal of antibiotics 2000/01/25, Vol.53(1), pp.45-49
Main Authors: SUZUKI, YOSHIKATSU, TAKAHASHI, HIROSHI, ESUMI, YASUAKI, ARIE, TSUTOMU, MORITA, TETSUICHIRO, KOSHINO, HIROYUKI, UZAWA, JUN, URAMOTO, MASAKAZU, YAMAGUCHI, ISAMU
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Applied microbiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
hematocin
Indoles - chemistry
Indoles - isolation & purification
Indoles - pharmacology
Medical sciences
Microbiology
Nectria haematococca
Oxepins - chemistry
Pharmacology. Drug treatments
Piperazines - chemistry
Piperazines - isolation & purification
Piperazines - pharmacology
Pyricularia oryzae
Stereoisomerism
Structure-Activity Relationship
Vegetables - drug effects
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Description
Summary:A new antifungal diketopiperazine named haematocin was isolated from the culture broth of Nectria haematococca Berk, et Br. (880701 a-1) causing blight disease on ornamental plants, Phalaenopsis spp. and Doritanopsis spp. Its structure was established by spectroscopic methods. Haematocin inhibited the germ-tube elongation and spore-germination of Pyricularia oryzae at the ED50 values of 30μg/ml and 160μg/ml, respectively.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.45