Antimicrobial Resistance Prevalence Rates in Hospital Antibiograms Reflect Prevalence Rates among Pathogens Associated with Hospital-Acquired Infections

To determine whether routine antibiograms (summaries reporting resistance of all tested isolates) reflect resistance rates among pathogens associated with hospital-acquired infections, we compared data collected from 2 different surveillance components in the same 166 intensive care units (ICUs). IC...

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Bibliographic Details
Published in:Clinical infectious diseases 2001-08, Vol.33 (3), p.324-329
Main Authors: Fridkin, Scott K., Edwards, Jonathan R., Tenover, Fred C., Gaynes, Robert P., McGowan, John E.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotic resistance
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobials
Biological and medical sciences
Cross Infection - epidemiology
Cross Infection - microbiology
Drug Resistance, Microbial
Epidemiologic Measurements
Hospital units
Humans
Infections
Intensive care units
Intensive Care Units - statistics & numerical data
Major Articles
Medical sciences
Microbial sensitivity tests
Pathogens
Pharmacology. Drug treatments
Prevalence
Reporting systems
Staphylococcus
Surveillance
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Summary:To determine whether routine antibiograms (summaries reporting resistance of all tested isolates) reflect resistance rates among pathogens associated with hospital-acquired infections, we compared data collected from 2 different surveillance components in the same 166 intensive care units (ICUs). ICUs reported data during the same months to both the infection-based surveillance and the laboratory-based surveillance. Paired comparisons of the percentage of isolates resistant were made between systems within each ICU. No significant differences existed (P > .05) between the percentage of isolates resistant from the infection-based system and laboratory-based system for all antimicrobial-resistant organisms studied, except methicillin resistance in Staphylococcus species. The mean difference in percentage resistance was higher from the infection-based system than the laboratory-based system for S. aureus (mean difference, +8%, P < .001) and coagulase-negative staphylococci (mean difference, +9%, P < .001). Overall, hospital antibiograms reflected susceptibility patterns among isolates associated with hospital-acquired infections. Hospital antibiograms may underestimate the relative frequency of methicillin resistance among Staphylococcus species when associated with hospital-acquired infections.
ISSN:1058-4838
1537-6591
DOI:10.1086/321893