Combined pre‐incisional oral dextromethorphan and epidural lidocaine for postoperative pain reduction and morphine sparing: a randomised double‐blind study on day‐surgery patients

The reduction in acute pain perception following dextromethorphan has previously been investigated in patients undergoing general anaesthesia. This random and double‐blind study examined the effects of pre‐incisional oral dextromethorphan on postoperative pain and intravenous patient‐controlled morp...

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Bibliographic Details
Published in:Anaesthesia 2001-07, Vol.56 (7), p.616-622
Main Authors: Weinbroum, A. A., Lalayev, G., Yashar, T., Ben‐Abraham, R., Niv, D., Flaishon, R.
Format: Article
Language:English
Subjects:
Aged
Ambulatory Surgical Procedures
Anaesthetic technique: epidural
Anaesthetics, local: lidocaine
Analgesia, Epidural
Analgesia, Patient-Controlled
Analgesics
Analgesics, Opioid - administration & dosage
Analgesics: morphine
Anesthetics, Local - therapeutic use
Biological and medical sciences
Dextromethorphan - therapeutic use
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Excitatory Amino Acid Antagonists - therapeutic use
Follow-Up Studies
Heart Rate - drug effects
Humans
Lidocaine - therapeutic use
Medical sciences
Middle Aged
Morphine - administration & dosage
Neuropharmacology
Pain, Postoperative - prevention & control
Pain: postoperative
Pharmacology. Drug treatments
Pharmacology: dextromethorphan
Respiration - drug effects
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Summary:The reduction in acute pain perception following dextromethorphan has previously been investigated in patients undergoing general anaesthesia. This random and double‐blind study examined the effects of pre‐incisional oral dextromethorphan on postoperative pain and intravenous patient‐controlled morphine demand in 60 day‐surgery patients undergoing lower body surgery under lidocaine (1.6%−16 ml) epidural anaesthesia after receiving placebo, 60 or 90 mg dextromethorphan, 90 min pre‐operatively. Postoperative pain was scored on a visual analogue scale from 1 to 10. In‐hospital observation continued for 6 h and for 3 days at home; diclofenac was available throughout. Dextromethorphan‐treated patients reported significantly (p 
ISSN:0003-2409
1365-2044
DOI:10.1046/j.1365-2044.2001.02088.x