Prevalence of upper respiratory symptoms in patients with symptomatic gastroesophageal reflux disease

This study evaluated the prevalence of upper respiratory symptoms (URS) among patients with symptomatic gastroesophageal reflux disease (GERD). Seventy-four subjects with heartburn completed a URS questionnaire before dual-probe, 24-h esophageal pH monitoring. The URS questionnaire was also complete...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2001-07, Vol.164 (1), p.72-76
Main Authors: THEODOROPOULOS, Demetrios S, LEDFORD, Dennis K, LOCKEY, Richard F, PECORARO, Donna L, RODRIGUEZ, John A, JOHNSON, Milton C, BOYCE, H. Worth
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Female
Florida - epidemiology
Gastroesophageal Reflux - complications
Gastroesophageal Reflux - diagnosis
Gastroesophageal Reflux - physiopathology
Humans
Male
Medical sciences
Middle Aged
Pneumology
Prevalence
Respiratory system : syndromes and miscellaneous diseases
Rhinitis - complications
Rhinitis - epidemiology
Rhinitis - physiopathology
Surveys and Questionnaires
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Summary:This study evaluated the prevalence of upper respiratory symptoms (URS) among patients with symptomatic gastroesophageal reflux disease (GERD). Seventy-four subjects with heartburn completed a URS questionnaire before dual-probe, 24-h esophageal pH monitoring. The URS questionnaire was also completed by 74 normal volunteers without previous or current symptoms of GERD. Esophageal pH monitoring results were classified as normal, distal, or proximal and distal gastroesophageal reflux using standardized criteria. Mean URS scores (+/- SD) were 8.31 +/- 3.98 in the 52 subjects with GERD and 4.57 +/- 3.57 in the 22 subjects with negative pH probe studies, p = 0.02. Subjects with negative pH probe studies and normal volunteers scored similarly on the URS questionnaire. Reflux episodes/24 h correlated with URS scores, r = 0.47, p = 0.0001. Seventy-five percent of subjects with upper reflux, 68% of subjects with lower reflux, 36% of subjects with normal esophageal pH studies, and 9% of normal volunteers reported laryngeal symptoms for at least 5 d/mo. Sixty-nine percent of subjects with upper reflux, 50% of subjects with lower reflux, 31% of subjects with normal pH studies, and 14% of normal volunteers reported nasal symptoms for at least 5 d/mo. URS are frequent among subjects with GERD. rhinitis; upper airway; gastroesophageal reflux
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.164.1.2006002