Simultaneous production of granulocyte colony‐stimulating factor and parathyroid hormone‐related protein in bladder cancer

A case of bladder cancer with simultaneous production of granulocyte colony‐stimulating factor (G‐CSF) and parathyroid hormone‐related protein (PTHrP) is reported. An 81‐year‐old male patient was admitted to the Saitama Medical School for treatment of gross hematuria, leukocytosis and hypercalcemia...

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Bibliographic Details
Published in:International journal of urology 2000-02, Vol.7 (2), p.72-75
Main Authors: Ueno, Munehisa, Ban, Shin‐Ichi, Ohigashi, Takashi, Nakanoma, Takashi, Nonaka, Shoichi, Hirata, Risa, Iida, Masahiro, Deguchi, Nobuhiro
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
bladder cancer
Granulocyte Colony-Stimulating Factor - biosynthesis
granulocyte colony‐stimulating factor
Humans
Male
Neoplasm Proteins - biosynthesis
Parathyroid Hormone-Related Protein
Protein Biosynthesis
Urinary Bladder Neoplasms - metabolism
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Summary:A case of bladder cancer with simultaneous production of granulocyte colony‐stimulating factor (G‐CSF) and parathyroid hormone‐related protein (PTHrP) is reported. An 81‐year‐old male patient was admitted to the Saitama Medical School for treatment of gross hematuria, leukocytosis and hypercalcemia and diagnosed as having advanced bladder cancer. Immediately after a cystectomy was carried out, his white cell count and serum calcium levels returned to normal. However, the tumors recurred locally and the recurrence was accompanied by an increase in the serum G‐CSF and PTHrP levels with a recurrent elevation of white cell count and the serum calcium level. The production of G‐CSF and PTHrP in the tumor cells was confirmed by immunohistochemistry.
ISSN:0919-8172
1442-2042
DOI:10.1046/j.1442-2042.2000.00141.x