Preliminary report: Amino acid profile in platelets of diabetic patients

Platelet levels of 19 amino acids were measured in 20 outpatients with type 1 (age [mean [plusmn] SE], 35.5 [plusmn] 2.0 years) and 27 with type 2 (age, 58.4 [plusmn] 1.4 years) diabetes, and 20 young (age 33.7 [plusmn] 1.3 years) and 20 older (age 57.4 [plusmn] 1.5 years) healthy volunteers. Platel...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2001-07, Vol.50 (7), p.739-741
Main Authors: De Luca, G., Calpona, P.R., Caponetti, A., Macaione, V., Di Benedetto, A., Cucinotta, D., Di Giorgio, R.M.
Format: Article
Language:English
Subjects:
Adult
Amino Acids - blood
Blood Platelets - metabolism
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - metabolism
Humans
Middle Aged
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Summary:Platelet levels of 19 amino acids were measured in 20 outpatients with type 1 (age [mean [plusmn] SE], 35.5 [plusmn] 2.0 years) and 27 with type 2 (age, 58.4 [plusmn] 1.4 years) diabetes, and 20 young (age 33.7 [plusmn] 1.3 years) and 20 older (age 57.4 [plusmn] 1.5 years) healthy volunteers. Platelet levels of most amino acids tended to be lower in patients with type 1 diabetes than in healthy controls. In particular, asparagine, glycine, taurine, alanine, valine, cysteine, leucine, phenylalanine, and lysine levels, expressed as nmol/10 8 platelets, were significantly lower. Only taurine significantly decreased in patients with type 2 diabetes, whereas threonine, alanine, and isoleucine increased.
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2001.24193