Primary Osteosarcoma of the Uterine Corpus: Report of a Case with Immunohistochemical and Ultrastructural Study

Background. Primary uterine osteosarcoma is extremely rare, with only 15 cases reported in the literature. Case. A 41-year-old woman presented with abnormal vaginal bleeding due to a large tumor arising from the uterine corpus. Histologically, the tumor showed the features of a malignant mesenchymal...

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Bibliographic Details
Published in:Gynecologic oncology 2001-07, Vol.82 (1), p.181-186
Main Authors: Hardisson, David, Simón, Raquel S., Burgos, Emilio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - analysis
carcinosarcoma
electron microscopy
Fatal Outcome
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunoenzyme Techniques
immunohistochemistry
malignant mixed müllerian tumor
Medical sciences
Middle Aged
Neoplasm Proteins - analysis
osteosarcoma
Osteosarcoma - chemistry
Osteosarcoma - therapy
Osteosarcoma - ultrastructure
Tumors
Uterine Neoplasms - chemistry
Uterine Neoplasms - therapy
Uterine Neoplasms - ultrastructure
uterus
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Summary:Background. Primary uterine osteosarcoma is extremely rare, with only 15 cases reported in the literature. Case. A 41-year-old woman presented with abnormal vaginal bleeding due to a large tumor arising from the uterine corpus. Histologically, the tumor showed the features of a malignant mesenchymal neoplasm with osteoid formation and lacked an epithelial component. Immunohistochemical and ultrastructural studies showed no evidence of epithelial differentiation. The tumor was excised and the patient received chemotherapy and radiation therapy postoperatively, but the tumor recurred locally at the 8-month follow-up. Conclusion. Osteosarcoma as a primary uterine tumor is exceedingly rare and should be distinguished from carcinosarcoma, which shows different macroscopic and histologic features. Prognosis of this neoplasm is very poor with an average life expectancy of 5 months.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.2001.6262