Chromophobe cell carcinoma and renal cell neoplasms with mucin-like changes

Hale's colloidal iron staining of 8 chromophobe cell carcinomas (CCC) was compared with that of non-chromophobe renal cell carcinomas (RCC), renal oncocytomas, and renal adenomas. Six non-chromophobe RCC showing diffuse and moderate cytoplasmic staining contained extensive areas with translucen...

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Bibliographic Details
Published in:Acta histochemica 2000, Vol.102 (1), p.103-113
Main Authors: Mai, Kien T., Burns, Bruce F.
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenoma - metabolism
Adenoma - pathology
Adenoma, Oxyphilic - metabolism
Adenoma, Oxyphilic - pathology
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
chromophobe
Diagnosis, Differential
Humans
Immunoenzyme Techniques
Iron
Keratins - metabolism
Kidney Neoplasms
mucin
Mucin-1 - metabolism
Neoplasm Proteins - metabolism
Neuraminidase
renal cell carcinoma
Vimentin - metabolism
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Summary:Hale's colloidal iron staining of 8 chromophobe cell carcinomas (CCC) was compared with that of non-chromophobe renal cell carcinomas (RCC), renal oncocytomas, and renal adenomas. Six non-chromophobe RCC showing diffuse and moderate cytoplasmic staining contained extensive areas with translucent cytoplasm as observed in CCC. Seventeen of 25 conventional RCC of the clear cell variant (randomly chosen from 130 cases), 21 of 26 RCC with areas of chromophilic cytoplasm, and 16 of 20 papillary RCC, 7 of 14 adenomas and 14 of 16 oncocytomas displayed focal areas with mild to moderate staining of the cytoplasm. Hale's colloidal iron staining was partially reduced by digestion with neuramidase but not with hyaluronidase. This positive staining demonstrated glycoproteins containing sialylated glycoconjugates, probably a type of acid epithelial mucin. We suggest that there is a spectrum of mucin-like changes in typical CCC representing RCC with extensive and marked “mucin-like changes”. The eosinophilic variant of CCC and some RCC with extensive chromophobe cell features represent renal neoplasms with moderate changes. The other RCC, oncocytomas and papillary renal neoplasms with mild to moderate staining with Hale's colloidal iron represent renal neoplasms with focal mucin-like changes. RCC with extensive chromophobe cell features may pose a differential diagnostic problem with CCC.
ISSN:0065-1281
1618-0372
DOI:10.1078/0065-1281-00543