Cytokine Profile in Genital Tract Secretions from Female Adolescents: Impact of Human Immunodeficiency Virus, Human Papillomavirus, and Other Sexually Transmitted Pathogens

Quantitative enzyme-linked immunosorbent assays were used to measure interleukin (IL)-2, IL-10, and IL-12 in cervical secretions from female adolescents with and without sexually transmitted infections. Compared with human immunodeficiency virus [HIV]-negative patients, HIV-positive patients had hig...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-03, Vol.181 (3), p.939-945
Main Authors: Crowley-Nowick, Peggy A., Ellenberg, Jonas H., Vermund, Sten H., Douglas, Steven D., Holland, Christie A., Moscicki, Anna-Barbara
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
AIDS/HIV
Cervical mucus
Cervix Mucus - chemistry
Cigarette smoking
Cytokines
Cytokines - analysis
Enzyme-Linked Immunosorbent Assay
Female
Genital Diseases, Female - immunology
Genitalia
HIV
HIV Infections - immunology
Human immunodeficiency virus
Human papillomavirus
Humans
Infections
Interleukin-10 - analysis
Interleukin-12 - analysis
Interleukin-2 - analysis
Major Articles
Modeling
Multivariate Analysis
Papillomaviridae
Papillomavirus Infections - immunology
Regression Analysis
Secretion
Sexually Transmitted Diseases - immunology
T lymphocytes
Tumor Virus Infections - immunology
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Summary:Quantitative enzyme-linked immunosorbent assays were used to measure interleukin (IL)-2, IL-10, and IL-12 in cervical secretions from female adolescents with and without sexually transmitted infections. Compared with human immunodeficiency virus [HIV]-negative patients, HIV-positive patients had higher concentrations of IL-10 (118.2 pg/mL vs. 34.5 pg/mL; P = .002) and IL-12 (175.5 pg/mL vs. 85.1; P = .03). IL-2 concentrations were not statistically different. Furthermore, genital tract infections were predictors of IL-10 and IL-12 concentrations. Coinfection with HIV and human papillomavirus predicted the highest IL-10 concentrations; coinfection with HIV, human papillomavirus, and other sexually transmitted pathogens predicted the highest IL-12 concentrations. The data indicate that concomitant infection of the genital tract with HIV and other viral, bacterial, or protozoan pathogens influences the local concentrations of some immunoregulatory cytokines.
ISSN:0022-1899
1537-6613
DOI:10.1086/315311