Perineural Invasion of Cutaneous Malignancies

Background. Perineural invasion is an important mode of tumor spread and is associated with increased aggressiveness and a propensity for recurrence among cutaneous malignancies. Objective. To review the pathogenesis, diagnosis, and treatment of cutaneous tumors exhibiting perineural invasion. Metho...

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Bibliographic Details
Published in:Dermatologic surgery 2001-06, Vol.27 (6), p.531-542
Main Authors: Feasel, Adrienne M., Brown, Tricia J., Bogle, Melissa A., Tschen, Jaime A., Nelson, Bruce R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dermatology
Humans
Medical sciences
Neoplasm Invasiveness
Peripheral Nervous System Neoplasms - prevention & control
Peripheral Nervous System Neoplasms - secondary
Skin Neoplasms - pathology
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Background. Perineural invasion is an important mode of tumor spread and is associated with increased aggressiveness and a propensity for recurrence among cutaneous malignancies. Objective. To review the pathogenesis, diagnosis, and treatment of cutaneous tumors exhibiting perineural invasion. Methods. This article is based on a review of the medical literature concerning tumors with perineural involvement. Results. This article describes the clinical signs and histologic features of cutaneous malignancies exhibiting perineural involvement. Conclusion. Appropriate patient care mandates consideration of perineural invasion in the evaluation of cutaneous tumors. As the majority of patients present without symptoms of neural involvement, physicians must be vigilant in the search for this type of tumor spread.
ISSN:1076-0512
1524-4725
DOI:10.1046/j.1524-4725.2001.00330.x