Regulation of ATP-Sensitive Potassium Channel mRNA Expression in Rat Kidney Following Ischemic Injury

ATP-sensitive potassium (KATP) channels are involved in the regulation of potassium homeostasis in kidneys. In the event of renal ischemia, they are thought to contribute to the important intracellular potassium loss observed in proximal tubules and thus to hypoxic injury. We have analyzed the trans...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2000-03, Vol.269 (2), p.618-622
Main Authors: Sgard, F., Faure, C., Drieu la Rochelle, C., Graham, D., O'Connor, S.E., Janiak, P., Besnard, F.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Glyceraldehyde-3-Phosphate Dehydrogenases - genetics
Ischemia - genetics
Kidney - blood supply
Kidney - metabolism
Male
Potassium Channels - genetics
Rats
Rats, Sprague-Dawley
RNA, Messenger - genetics
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Summary:ATP-sensitive potassium (KATP) channels are involved in the regulation of potassium homeostasis in kidneys. In the event of renal ischemia, they are thought to contribute to the important intracellular potassium loss observed in proximal tubules and thus to hypoxic injury. We have analyzed the transcriptional regulation of KATP genes in rat kidney following transient renal ischemia.We observed that mRNA expression level was down-regulated for Kir1.1 and Kir4.1 potassium channels between 24 and 120 h after ischemia. In contrast, a strong increase in mRNA expression was observed for Kir6.1 shortly (2–6 h) after ischemia. Thus, renal ischemia followed by reperfusion provokes differential regulation of KATP channel gene expression.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.2000.2342