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Clinical significance of increased plasma concentration of macrophage colony–stimulating factor in patients with angina pectoris
OBJECTIVES To determine the effect of macrophage colony–stimulating factor (MCSF) on atherogenesis in patients with coronary artery disease (CAD), we assessed the relation between the plasma concentration of MCSF and the incidence of acute coronary events in patients with CAD. BACKGROUND Cytokines s...
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| Published in: | Journal of the American College of Cardiology 2000-03, Vol.35 (3), p.655-665 |
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| cited_by | cdi_FETCH-LOGICAL-c424t-d695f77868e010befa00bc3a571dfe8e2c84bd3543ffc45ee8d88e1271548bc73 |
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| cites | cdi_FETCH-LOGICAL-c424t-d695f77868e010befa00bc3a571dfe8e2c84bd3543ffc45ee8d88e1271548bc73 |
| container_end_page | 665 |
| container_issue | 3 |
| container_start_page | 655 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 35 |
| creator | Saitoh, Tsutomu Kishida, Hiroshi Tsukada, Yayoi Fukuma, Yumiko Sano, Junko Yasutake, Masahiro Fukuma, Nagaharu Kusama, Yoshiki Hayakawa, Hirokazu |
| description | OBJECTIVES
To determine the effect of macrophage colony–stimulating factor (MCSF) on atherogenesis in patients with coronary artery disease (CAD), we assessed the relation between the plasma concentration of MCSF and the incidence of acute coronary events in patients with CAD.
BACKGROUND
Cytokines such as MCSF play a central role in inflammatory and proliferative responses in patients with acute coronary syndromes. However, the effect of MCSF on the clinical course in patients with CAD is still not known.
METHODS
We measured the plasma MCSF concentration in 142 patients with documented CAD (62 ± 9 years) and followed up for a mean period of 14 ± 6 months. The study included 97 patients with stable angina (SA), 45 patients with unstable angina (UA) and 22 age-matched control subjects. The predictors of coronary events were analyzed by using a Cox proportional hazards model.
RESULTS
The mean plasma MCSF concentration in patients with UA was significantly higher than that in patients with SA and in control subjects (981 ± 277 vs. 693 ± 223 vs. 680 ± 158 pg/ml, p < 0.001). The mean plasma MCSF concentration in the 20 patients with coronary events was significantly higher than that in patients without coronary events (1,192 ± 232 vs. 690 ± 213 pg/ml, p < 0.001). The predictors of unfavorable outcome were an increased MCSF concentration, the presence of CAD and a low ejection fraction.
CONCLUSIONS
These findings suggest that an increased circulating MCSF concentration reflects atherosclerotic progression in patients with CAD and predicts future cardiac events. |
| doi_str_mv | 10.1016/S0735-1097(99)00583-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70984939</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0735109799005835</els_id><sourcerecordid>70984939</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-d695f77868e010befa00bc3a571dfe8e2c84bd3543ffc45ee8d88e1271548bc73</originalsourceid><addsrcrecordid>eNqFkE9vFCEYh4nR2LX6ETQcTGMPU2FnGODUmI39kzTpQT0ThnnZYmZg5J3V9Nb4FfoN_SRluxvtzROE3_N7gYeQt5ydcMbbj1-YrEXFmZYftD5mTKi6Es_Igguhqlpo-Zws_iIH5BXid8ZYq7h-SQ44k7xtWrUgv1dDiMHZgWJYx-DLNjqgydMQXQaL0NNpsDha6lJJ4pztHFLcEqN1OU03dg0lG1K8_XN3j3MYN0NB4pp66-aUyyA6lYNSRforzDfUxnWIlk6wjQO-Ji-8HRDe7NdD8u3s89fVRXV1fX65-nRVuWbZzFXfauGlVK0CxlkH3jLWudoKyXsPCpZONV1fi6b23jUCQPVKAV9KLhrVOVkfkqPd3CmnHxvA2YwBHQyDjZA2aCTTqtG1LqDYgeV7iBm8mXIYbb41nJmtfPMo32zNGq3No3wjSu_d_oJNN0L_pLWzXYD3e8BiUe5zcR3wH7dUWitWsNMdBsXGzwDZoCv6HPQhF2emT-E_L3kAOGOlig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70984939</pqid></control><display><type>article</type><title>Clinical significance of increased plasma concentration of macrophage colony–stimulating factor in patients with angina pectoris</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Saitoh, Tsutomu ; Kishida, Hiroshi ; Tsukada, Yayoi ; Fukuma, Yumiko ; Sano, Junko ; Yasutake, Masahiro ; Fukuma, Nagaharu ; Kusama, Yoshiki ; Hayakawa, Hirokazu</creator><creatorcontrib>Saitoh, Tsutomu ; Kishida, Hiroshi ; Tsukada, Yayoi ; Fukuma, Yumiko ; Sano, Junko ; Yasutake, Masahiro ; Fukuma, Nagaharu ; Kusama, Yoshiki ; Hayakawa, Hirokazu</creatorcontrib><description>OBJECTIVES
To determine the effect of macrophage colony–stimulating factor (MCSF) on atherogenesis in patients with coronary artery disease (CAD), we assessed the relation between the plasma concentration of MCSF and the incidence of acute coronary events in patients with CAD.
BACKGROUND
Cytokines such as MCSF play a central role in inflammatory and proliferative responses in patients with acute coronary syndromes. However, the effect of MCSF on the clinical course in patients with CAD is still not known.
METHODS
We measured the plasma MCSF concentration in 142 patients with documented CAD (62 ± 9 years) and followed up for a mean period of 14 ± 6 months. The study included 97 patients with stable angina (SA), 45 patients with unstable angina (UA) and 22 age-matched control subjects. The predictors of coronary events were analyzed by using a Cox proportional hazards model.
RESULTS
The mean plasma MCSF concentration in patients with UA was significantly higher than that in patients with SA and in control subjects (981 ± 277 vs. 693 ± 223 vs. 680 ± 158 pg/ml, p < 0.001). The mean plasma MCSF concentration in the 20 patients with coronary events was significantly higher than that in patients without coronary events (1,192 ± 232 vs. 690 ± 213 pg/ml, p < 0.001). The predictors of unfavorable outcome were an increased MCSF concentration, the presence of CAD and a low ejection fraction.
CONCLUSIONS
These findings suggest that an increased circulating MCSF concentration reflects atherosclerotic progression in patients with CAD and predicts future cardiac events.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(99)00583-5</identifier><identifier>PMID: 10716468</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Angina Pectoris - blood ; Angina Pectoris - diagnostic imaging ; Angina Pectoris - therapy ; Angioplasty, Balloon, Coronary ; Biological and medical sciences ; Biomarkers - blood ; Cardiology. Vascular system ; Coronary Angiography ; Coronary Artery Bypass ; Coronary heart disease ; Disease Progression ; Electrocardiography ; Female ; Heart ; Humans ; Macrophage Colony-Stimulating Factor - blood ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Risk Factors ; Stroke Volume</subject><ispartof>Journal of the American College of Cardiology, 2000-03, Vol.35 (3), p.655-665</ispartof><rights>2000 American College of Cardiology</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-d695f77868e010befa00bc3a571dfe8e2c84bd3543ffc45ee8d88e1271548bc73</citedby><cites>FETCH-LOGICAL-c424t-d695f77868e010befa00bc3a571dfe8e2c84bd3543ffc45ee8d88e1271548bc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1289980$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10716468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saitoh, Tsutomu</creatorcontrib><creatorcontrib>Kishida, Hiroshi</creatorcontrib><creatorcontrib>Tsukada, Yayoi</creatorcontrib><creatorcontrib>Fukuma, Yumiko</creatorcontrib><creatorcontrib>Sano, Junko</creatorcontrib><creatorcontrib>Yasutake, Masahiro</creatorcontrib><creatorcontrib>Fukuma, Nagaharu</creatorcontrib><creatorcontrib>Kusama, Yoshiki</creatorcontrib><creatorcontrib>Hayakawa, Hirokazu</creatorcontrib><title>Clinical significance of increased plasma concentration of macrophage colony–stimulating factor in patients with angina pectoris</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>OBJECTIVES
To determine the effect of macrophage colony–stimulating factor (MCSF) on atherogenesis in patients with coronary artery disease (CAD), we assessed the relation between the plasma concentration of MCSF and the incidence of acute coronary events in patients with CAD.
BACKGROUND
Cytokines such as MCSF play a central role in inflammatory and proliferative responses in patients with acute coronary syndromes. However, the effect of MCSF on the clinical course in patients with CAD is still not known.
METHODS
We measured the plasma MCSF concentration in 142 patients with documented CAD (62 ± 9 years) and followed up for a mean period of 14 ± 6 months. The study included 97 patients with stable angina (SA), 45 patients with unstable angina (UA) and 22 age-matched control subjects. The predictors of coronary events were analyzed by using a Cox proportional hazards model.
RESULTS
The mean plasma MCSF concentration in patients with UA was significantly higher than that in patients with SA and in control subjects (981 ± 277 vs. 693 ± 223 vs. 680 ± 158 pg/ml, p < 0.001). The mean plasma MCSF concentration in the 20 patients with coronary events was significantly higher than that in patients without coronary events (1,192 ± 232 vs. 690 ± 213 pg/ml, p < 0.001). The predictors of unfavorable outcome were an increased MCSF concentration, the presence of CAD and a low ejection fraction.
CONCLUSIONS
These findings suggest that an increased circulating MCSF concentration reflects atherosclerotic progression in patients with CAD and predicts future cardiac events.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina Pectoris - blood</subject><subject>Angina Pectoris - diagnostic imaging</subject><subject>Angina Pectoris - therapy</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Bypass</subject><subject>Coronary heart disease</subject><subject>Disease Progression</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Macrophage Colony-Stimulating Factor - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Stroke Volume</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkE9vFCEYh4nR2LX6ETQcTGMPU2FnGODUmI39kzTpQT0ThnnZYmZg5J3V9Nb4FfoN_SRluxvtzROE3_N7gYeQt5ydcMbbj1-YrEXFmZYftD5mTKi6Es_Igguhqlpo-Zws_iIH5BXid8ZYq7h-SQ44k7xtWrUgv1dDiMHZgWJYx-DLNjqgydMQXQaL0NNpsDha6lJJ4pztHFLcEqN1OU03dg0lG1K8_XN3j3MYN0NB4pp66-aUyyA6lYNSRforzDfUxnWIlk6wjQO-Ji-8HRDe7NdD8u3s89fVRXV1fX65-nRVuWbZzFXfauGlVK0CxlkH3jLWudoKyXsPCpZONV1fi6b23jUCQPVKAV9KLhrVOVkfkqPd3CmnHxvA2YwBHQyDjZA2aCTTqtG1LqDYgeV7iBm8mXIYbb41nJmtfPMo32zNGq3No3wjSu_d_oJNN0L_pLWzXYD3e8BiUe5zcR3wH7dUWitWsNMdBsXGzwDZoCv6HPQhF2emT-E_L3kAOGOlig</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Saitoh, Tsutomu</creator><creator>Kishida, Hiroshi</creator><creator>Tsukada, Yayoi</creator><creator>Fukuma, Yumiko</creator><creator>Sano, Junko</creator><creator>Yasutake, Masahiro</creator><creator>Fukuma, Nagaharu</creator><creator>Kusama, Yoshiki</creator><creator>Hayakawa, Hirokazu</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000301</creationdate><title>Clinical significance of increased plasma concentration of macrophage colony–stimulating factor in patients with angina pectoris</title><author>Saitoh, Tsutomu ; Kishida, Hiroshi ; Tsukada, Yayoi ; Fukuma, Yumiko ; Sano, Junko ; Yasutake, Masahiro ; Fukuma, Nagaharu ; Kusama, Yoshiki ; Hayakawa, Hirokazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-d695f77868e010befa00bc3a571dfe8e2c84bd3543ffc45ee8d88e1271548bc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angina Pectoris - blood</topic><topic>Angina Pectoris - diagnostic imaging</topic><topic>Angina Pectoris - therapy</topic><topic>Angioplasty, Balloon, Coronary</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Bypass</topic><topic>Coronary heart disease</topic><topic>Disease Progression</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Macrophage Colony-Stimulating Factor - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Stroke Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saitoh, Tsutomu</creatorcontrib><creatorcontrib>Kishida, Hiroshi</creatorcontrib><creatorcontrib>Tsukada, Yayoi</creatorcontrib><creatorcontrib>Fukuma, Yumiko</creatorcontrib><creatorcontrib>Sano, Junko</creatorcontrib><creatorcontrib>Yasutake, Masahiro</creatorcontrib><creatorcontrib>Fukuma, Nagaharu</creatorcontrib><creatorcontrib>Kusama, Yoshiki</creatorcontrib><creatorcontrib>Hayakawa, Hirokazu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saitoh, Tsutomu</au><au>Kishida, Hiroshi</au><au>Tsukada, Yayoi</au><au>Fukuma, Yumiko</au><au>Sano, Junko</au><au>Yasutake, Masahiro</au><au>Fukuma, Nagaharu</au><au>Kusama, Yoshiki</au><au>Hayakawa, Hirokazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of increased plasma concentration of macrophage colony–stimulating factor in patients with angina pectoris</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>35</volume><issue>3</issue><spage>655</spage><epage>665</epage><pages>655-665</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>OBJECTIVES
To determine the effect of macrophage colony–stimulating factor (MCSF) on atherogenesis in patients with coronary artery disease (CAD), we assessed the relation between the plasma concentration of MCSF and the incidence of acute coronary events in patients with CAD.
BACKGROUND
Cytokines such as MCSF play a central role in inflammatory and proliferative responses in patients with acute coronary syndromes. However, the effect of MCSF on the clinical course in patients with CAD is still not known.
METHODS
We measured the plasma MCSF concentration in 142 patients with documented CAD (62 ± 9 years) and followed up for a mean period of 14 ± 6 months. The study included 97 patients with stable angina (SA), 45 patients with unstable angina (UA) and 22 age-matched control subjects. The predictors of coronary events were analyzed by using a Cox proportional hazards model.
RESULTS
The mean plasma MCSF concentration in patients with UA was significantly higher than that in patients with SA and in control subjects (981 ± 277 vs. 693 ± 223 vs. 680 ± 158 pg/ml, p < 0.001). The mean plasma MCSF concentration in the 20 patients with coronary events was significantly higher than that in patients without coronary events (1,192 ± 232 vs. 690 ± 213 pg/ml, p < 0.001). The predictors of unfavorable outcome were an increased MCSF concentration, the presence of CAD and a low ejection fraction.
CONCLUSIONS
These findings suggest that an increased circulating MCSF concentration reflects atherosclerotic progression in patients with CAD and predicts future cardiac events.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10716468</pmid><doi>10.1016/S0735-1097(99)00583-5</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 2000-03, Vol.35 (3), p.655-665 |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Adult Aged Aged, 80 and over Angina Pectoris - blood Angina Pectoris - diagnostic imaging Angina Pectoris - therapy Angioplasty, Balloon, Coronary Biological and medical sciences Biomarkers - blood Cardiology. Vascular system Coronary Angiography Coronary Artery Bypass Coronary heart disease Disease Progression Electrocardiography Female Heart Humans Macrophage Colony-Stimulating Factor - blood Male Medical sciences Middle Aged Prognosis Proportional Hazards Models Risk Factors Stroke Volume |
| title | Clinical significance of increased plasma concentration of macrophage colony–stimulating factor in patients with angina pectoris |
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