Factors influencing B lymphopoiesis after allogeneic hematopoietic cell transplantation

In 93 allograft recipients, the numbers of marrow B-cell precursors on days 80 and 365 correlated with the counts of circulating B cells, suggesting that the posttransplantation B-cell deficiency is at least in part due to insufficient B lymphopoiesis. Factors that could affect B lymphopoiesis were...

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Bibliographic Details
Published in:Blood 2001-07, Vol.98 (2), p.489-491
Main Authors: Storek, Jan, Wells, Denise, Dawson, Monja A., Storer, Barry, Maloney, David G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
B-Lymphocytes
Biological and medical sciences
Bone Marrow Cells - pathology
Bone Marrow Transplantation
Bone marrow, stem cells transplantation. Graft versus host reaction
Cell Count
Chronic Disease
Female
Graft vs Host Disease - pathology
Hematopoiesis
Hematopoietic Stem Cell Transplantation
Humans
Lymphocyte Count
Male
Medical sciences
Middle Aged
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:In 93 allograft recipients, the numbers of marrow B-cell precursors on days 80 and 365 correlated with the counts of circulating B cells, suggesting that the posttransplantation B-cell deficiency is at least in part due to insufficient B lymphopoiesis. Factors that could affect B lymphopoiesis were evaluated. The number of marrow B-cell precursors on days 30 and 80 was at least 4-fold lower in patients with grade 2 to 4 acute graft-versus-host disease (GVHD) compared with patients with grade 0 to 1 acute GVHD. The number of B-cell precursors on day 365 was 18-fold lower in patients with extensive chronic GVHD compared with patients with no or limited chronic GVHD. The number of B-cell precursors was not related to CD34 cell dose, type of transplant (marrow versus blood stem cells), donor age, or patient age. It was concluded that posttransplantation B-cell deficiency results in part from inhibition of B lymphopoiesis by GVHD and/or its treatment.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V98.2.489