Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD

Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death, with cigarette smoking among the main risk factors. Hallmarks of COPD include chronic airflow obstruction and chronic inflammation in the airway walls or alveolar septa. An earlier study reported elevated numbers...

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Bibliographic Details
Published in:The Journal of pathology 2000-04, Vol.190 (5), p.619-626
Main Authors: de Boer, Willem I., Sont, Jacob K., van Schadewijk, Annemarie, Stolk, Jan, van Krieken, J. Han, Hiemstra, Pieter S.
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS/HIV
Bronchi - metabolism
CCR2
CD8-Positive T-Lymphocytes - pathology
Chemokine CCL2 - genetics
Chemokine CCL2 - metabolism
COPD
Epithelium - metabolism
Female
human
Humans
IL-8
Immunoenzyme Techniques
immunohistochemistry
In Situ Hybridization
Interleukin-8 - genetics
Interleukin-8 - metabolism
lung
Lung Diseases, Obstructive - metabolism
Lymphocyte Count
Male
MCP-1
Middle Aged
Pulmonary Alveoli - metabolism
Retrospective Studies
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death, with cigarette smoking among the main risk factors. Hallmarks of COPD include chronic airflow obstruction and chronic inflammation in the airway walls or alveolar septa. An earlier study reported elevated numbers of macrophages and mast cells within the bronchiolar epithelium in smokers with COPD, compared with smokers without. Since specific chemokines may be involved in this influx, the in situ protein and mRNA expression of monocyte chemoattractant protein 1 (MCP‐1) and of interleukin 8 (IL‐8) were studied in tumour‐free peripheral lung tissue resected for lung cancer of current or ex‐smokers with COPD (FEV184; n=14). MCP‐1 was expressed by macrophages, T cells, and endothelial and epithelial cells. Its receptor, CCR2, is expressed by macrophages, mast cells, and epithelial cells. IL‐8 was found in neutrophils, epithelial cells, and macrophages. In subjects with COPD, semi‐quantitative analysis revealed 1.5‐fold higher levels of MCP‐1 mRNA and IL‐8 mRNA and protein in bronchiolar epithelium (p
ISSN:0022-3417
1096-9896
DOI:10.1002/(SICI)1096-9896(200004)190:5<619::AID-PATH555>3.0.CO;2-6