Low Dose Cyclosporin A Treatment in Generalized Pustular Psoriasis

: Generalized pustular psoriasis is a rare form of psoriasis, seldom seen in children. Three patients with generalized pustular psoriasis are presented, two of whom were a sister and brother and whose grandfather also had pustular psoriasis. Lesions consisted of pustular, erythematous, scaly, follic...

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Bibliographic Details
Published in:Pediatric dermatology 2001-05, Vol.18 (3), p.246-248
Main Authors: Kiliç, S. Şebnem, Hacimustafaoğlu, Mustafa, Çelebi, Solmaz, Karadeniz, Aynur, Ildirim, Ibrahim
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Cyclosporine - administration & dosage
Dermatologic Agents - administration & dosage
Female
Humans
Immunosuppressive Agents - administration & dosage
Infant
Male
Medical sciences
Pharmacology. Drug treatments
Psoriasis - drug therapy
Psoriasis - genetics
Psoriasis - pathology
Skin, nail, hair, dermoskeleton
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Summary:: Generalized pustular psoriasis is a rare form of psoriasis, seldom seen in children. Three patients with generalized pustular psoriasis are presented, two of whom were a sister and brother and whose grandfather also had pustular psoriasis. Lesions consisted of pustular, erythematous, scaly, follicular papules located on the trunk, scalp, and extremities. The pustules in some areas coalesced to form lakes. Histologic examination of several biopsy specimens revealed the changes of pustular psoriasis, which were parakeratosis, elongation of the rete ridges, and deep spongioform pustules and Munro abscesses. All patients were treated with cyclosporin A for periods of 2–12 months. The doses ranged from 1 to 2 mg/kg/day. Clearance of psoriatic lesions occurred after 2–4 weeks of therapy.
ISSN:0736-8046
1525-1470
DOI:10.1046/j.1525-1470.2001.018003246.x