Developmental regulation of membrane type-5 matrix metalloproteinase (MT5-MMP) expression in the rat nervous system

An intricate balance between extracellular matrix (ECM) synthesis and degradation must be maintained during developmental tissue remodeling. Matrix metalloproteinases (MMPs) are the main mediators of ECM degradation. A subset of MMPs, referred to as membrane-type MMPs, contains a transmembrane domai...

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Bibliographic Details
Published in:Brain research 2000-03, Vol.860 (1), p.174-177
Main Author: Jaworski, Diane M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - embryology
Brain - enzymology
CNS
Development
Development. Senescence. Regeneration. Transplantation
DNA, Complementary - genetics
Enzyme Induction
Extracellular matrix
Extracellular Matrix - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Gestational Age
In Situ Hybridization
Matrix metalloproteinase
matrix metalloproteinases
Matrix Metalloproteinases, Membrane-Associated
Metalloendopeptidases - biosynthesis
Metalloendopeptidases - genetics
MMP
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Rats
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
Spinal Cord - embryology
Spinal Cord - enzymology
Vertebrates: nervous system and sense organs
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Summary:An intricate balance between extracellular matrix (ECM) synthesis and degradation must be maintained during developmental tissue remodeling. Matrix metalloproteinases (MMPs) are the main mediators of ECM degradation. A subset of MMPs, referred to as membrane-type MMPs, contains a transmembrane domain that restricts protease activity at the cell surface. Membrane type-5 MMP is predominantly expressed in the brain. The present report is the first to demonstrate the temporal regulation and spatial distribution of MT5-MMP mRNA during nervous system development.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(00)02035-7