Molecular Epidemiology of Community-Acquired Staphylococcus aureus in Families with and without Cystic Fibrosis Patients

The molecular epidemiology of Staphylococcus aureus nasal commensal strains and community-acquired infecting strains was assessed by comparison of prevalence, persistence, transmission rate, and clonal distribution of S. aureus in families with and without cystic fibrosis (CF) patients. Isolates wer...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-03, Vol.181 (3), p.984-989
Main Authors: Goerke, Christiane, Kraning, Kerstin, Stern, Martin, Döring, Gerd, Botzenhart, Konrad, Wolz, Christiane
Format: Article
Language:English
Subjects:
Antibiotics
Bacteriophage typing
Community-Acquired Infections - microbiology
Cystic fibrosis
Cystic Fibrosis - microbiology
endocarditis
Epidemiology
Gels
Genomes
Genotype
Humans
Infections
iron
Major Articles
Microbial colonization
Nasal Mucosa - microbiology
oxygen
Pseudomonas aeruginosa
pvdS gene
sigma factor
Sputum
Sputum - microbiology
Staphylococcus aureus
Staphylococcus aureus - classification
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
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Summary:The molecular epidemiology of Staphylococcus aureus nasal commensal strains and community-acquired infecting strains was assessed by comparison of prevalence, persistence, transmission rate, and clonal distribution of S. aureus in families with and without cystic fibrosis (CF) patients. Isolates were typed by pulsed-field gel electrophoresis. CF patients without antibiotic treatment had a significantly higher nasal prevalence (66%) of S. aureus than did treated patients (29%; < .001) or healthy controls (32%; < .001), suggesting that persons with CF have a higher susceptibility to this organism. Strain transmission was frequent within both CF (55%) and non-CF (62%) families. After 3 and 19 months, 57% and 21%, respectively, of all persons still harbored the same S. aureus strain. Most of the isolates (78%) belonged to 8 of 38 genome types common in CF patients and in healthy persons. The predominant occurrence of a limited number of S. aureus clones within the community suggests evolutionary mechanisms for the selection of certain strains without an obvious association with disease.
ISSN:0022-1899
1537-6613
DOI:10.1086/315331