The relationship of lymphocytes in blood and in lymph to sleep/wake states in sheep

Based on evidence of a role for immune-associated cytokines in sleep induction, we investigated the possibility that lymphocyte distribution between blood and lymphatics could be altered as a function of sleep/wakefulness. Blood and lymph sample were obtained from 5 sheep during periods of slow-wave...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2000-03, Vol.23 (2), p.185-190
Main Authors: DICKSTEIN, J. B, HAY, J. B, ENG, F. A. L. M, MOLDOFSKY, H
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Antigens, CD - immunology
Antigens, Surface - immunology
Biological and medical sciences
Cell Movement - physiology
Cytokines - blood
Female
Fundamental and applied biological sciences. Psychology
Lymph - metabolism
Lymphocyte Subsets - immunology
Lymphocyte Subsets - metabolism
Sheep - physiology
Sleep, REM - physiology
Sleep. Vigilance
Vertebrates: nervous system and sense organs
Wakefulness - physiology
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Summary:Based on evidence of a role for immune-associated cytokines in sleep induction, we investigated the possibility that lymphocyte distribution between blood and lymphatics could be altered as a function of sleep/wakefulness. Blood and lymph sample were obtained from 5 sheep during periods of slow-wave sleep and wake. Blood and lymph lymphocytes were phenotyped using monoclonal antibodies against CD4, CD8, gd T-cell receptors and a surface marker on ovine B cells. Lymph flow rates and efferent lymph cell output were measured. Lymph flow and prescapular efferent lymphocyte output were reduced during sleep compared to wakefulness (p
ISSN:0161-8105
1550-9109
1550-9109
DOI:10.1093/sleep/23.2.1e