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The relationship of lymphocytes in blood and in lymph to sleep/wake states in sheep

Based on evidence of a role for immune-associated cytokines in sleep induction, we investigated the possibility that lymphocyte distribution between blood and lymphatics could be altered as a function of sleep/wakefulness. Blood and lymph sample were obtained from 5 sheep during periods of slow-wave...

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Published in:	Sleep (New York, N.Y.) N.Y.), 2000-03, Vol.23 (2), p.185-190
Main Authors:	DICKSTEIN, J. B, HAY, J. B, ENG, F. A. L. M, MOLDOFSKY, H
Format:	Article
Language:	English
Subjects:	Animals Antibodies, Monoclonal - immunology Antigens, CD - immunology Antigens, Surface - immunology Biological and medical sciences Cell Movement - physiology Cytokines - blood Female Fundamental and applied biological sciences. Psychology Lymph - metabolism Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Sheep - physiology Sleep, REM - physiology Sleep. Vigilance Vertebrates: nervous system and sense organs Wakefulness - physiology
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container_title	Sleep (New York, N.Y.)
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creator	DICKSTEIN, J. B HAY, J. B ENG, F. A. L. M MOLDOFSKY, H
description	Based on evidence of a role for immune-associated cytokines in sleep induction, we investigated the possibility that lymphocyte distribution between blood and lymphatics could be altered as a function of sleep/wakefulness. Blood and lymph sample were obtained from 5 sheep during periods of slow-wave sleep and wake. Blood and lymph lymphocytes were phenotyped using monoclonal antibodies against CD4, CD8, gd T-cell receptors and a surface marker on ovine B cells. Lymph flow rates and efferent lymph cell output were measured. Lymph flow and prescapular efferent lymphocyte output were reduced during sleep compared to wakefulness (p
doi_str_mv	10.1093/sleep/23.2.1e
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subjects	Animals Antibodies, Monoclonal - immunology Antigens, CD - immunology Antigens, Surface - immunology Biological and medical sciences Cell Movement - physiology Cytokines - blood Female Fundamental and applied biological sciences. Psychology Lymph - metabolism Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Sheep - physiology Sleep, REM - physiology Sleep. Vigilance Vertebrates: nervous system and sense organs Wakefulness - physiology
title	The relationship of lymphocytes in blood and in lymph to sleep/wake states in sheep
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